CT Photothermal Maltzahn 2009 Fig 4da
Nanopartz™ Nanorods™ were intratumorally given to mice bearing bilateral MDA-MB-435 tumors and imaged using X-ray CT to visualize three-dimensional distribution in tumors.
  • Nanopartz™ Nanorods™ were intratumorally given to mice bearing bilateral MDA-MB-435 tumors and imaged using X-ray CT to visualize three-dimensional distribution in tumors.
  • A three-dimensional solid model of the complete geometry was rapidly reconstructed by image processing for use with computational photothermal modeling.
  • Red, PEG-NRs. Experimental thermographic surveillance of NIR irradiation after X-ray CT (~0.75 W/cm2 , 1 min; bottom). From MIT/Nanopartz Collaboration 2009.
  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)
  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
  • Image of Nanopartz GNR labeled cell subsequently labeled with the live cell dye Calcein-AM, shown in red. From Motamedi 2011 BOE (2)5. NCBI Copyright Approval.
  • Two Photon Image of Nanopartz GNR labeled cells using an incident power of 0.7mW overlayed with corresponding transmitted light micrograph. From Motmaedi 2011 BOE(2)5. NCBI Copyright Approved.
  • Two photon image using low incident power of 1mW following intravenous injection of Nanopartz gold nanorods in Hamster Model showing blood vessels in the tissue. From Motamedi 2011 BOE (2) 5. NCBI Copyright Approved.
  • White light microscopy images of control tumor and GNS and Nanopartz Ntracker GNR injected mice. (Pink: cytoplasm stained with eosin, Dark Blue: nuclei stained with hematoxylin). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Tumor model (Green: cytoplasm stained with eosin, Yellow: GNSs and Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Nanopartz gold nanorod injected mice with nuclei staning (YOYO-1 iodide). Two photon IP image with FOV of 720x490um measured at the distance of approximately 100um inside the tumor edge. (Green: nuclei, Yellow: Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of Nanopartz gold nanorod injected mice with blood vessel staining (CD31 immunofluorescence staining). TPIP image with FOV of 790x520um. Red: blood vessels, Yellow: Nanopartz Ntracker Gold Nanorods. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of liver of Nanopartz Ntracker gold nanorod injected mice. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • In vivo imaging of single gold nanorods in mice ear blood vessels. Overlay of transmission image (light blue) and a single frame TPL image. Two single nanorods (red spots) are superimposed by a linescan (white). From Wei Nanomedicine (Lond). 2007 February 2(1) 125-132. NCBI Copyright Approval.
  • B Mode and photoacoustic images of subcutaneous tumor before and 2 minutes after a 200uL bolus of Nanopartz gold nanorods. Photoacoustic contrast in enhanced by gold nanorods in vasculature. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised spleen of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse spleen. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 970nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Gold nanorod contrast enhanced Optical Coherence Tomography images of a human breast carcinoma tissue sample. The sturcutral OCT image is presented in red, and the SOCT computed GNR density is presented in green.

Nanopartz™ Ntracker™ and Ntherapy™ for in vivo Imaging

Nanopartz™ Ntracker™ and Ntherapy™ nanorods for in vivo imaging are gold nanorods specifically for use in in vivo imaging applications such as cancer therapy research utilizing Two Photon Fluorescence, Optical Coherence Tomography, Photoacoustic Imaging, CT, Photothermal Imaging, and other imaging modeities. Ntracker™ nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. Ntherapy™ nanorods come with similar hydrophilic polymers, but with terminal amine and carboxyl active groups, along with a number of custom popular in vivo targeting ligands. Ntherapy™ also provides an opportunity for the customer to define their own targeting ligands utilizing Nanopartz™ nanorod and polymer technologies. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting. As opposed to other commercially available nanoparticles such as quantum dots, Nanopartz™ in vivo line of nanorods are completely non-toxic. Whereas Ntracker™ takes advantage of Enhanced Permeability and Retention effect (EPR) for passive in vivo targeting, Ntherapy™ utilizes popular ligands for active targeting. This product line comes in a diameter of 10nm with SPRs matching all of the popular Near IR CW laser wavelengths; 780, 808, 850, 980, and 1064nm. Ntherapy™ offers options for oligo and customer detailed conjugations. Every batch is radiation sterilized in PBS, and comes with instructions for in vivo mouse iv injection. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped next day for many ligands. This product comes in two concentrations, regular 1.75mg/mL, and highly concentrated 10mg/mL.

Home » D- In Vivo Gold Nanoparticles » DI- In Vivo Imaging
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Ntherapy
Ntherapy
Part# D12-(SPR)-(Conjugation)-(Wt. conc)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Price: $480.00
Ntracker
Ntracker
Part# D12M-(SPR)-(Wt.conc)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Price: $480.00
In-Vivo Plasmonic Fluorophores
In-Vivo Plasmonic Fluorophores
Part # D16-(DIAM-SPR)-(CONJUGATION)-(OD-mLs)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Negative Control
0.1mL Nonreactive Methyl (+$100.00)
1mL Nonreactive Methyl (+$480.00)
Price: $480.00

 

 

 

Part # Diameter (nm) Length (nm) Peak SPR Wave (nm) Aspect Ratio OD SPR (AU) Peak LSPR Wave (nm) OD LSPR (AU) Nanorod Vol (nm3) Nanorods /mL Wt. conc (mg/ml) Wt. % PPM Molarity (nM) SPR Molar Ext. (M-1cm-1) LSPR Molar Ext. (M-1cm-1) Peak SPR accuracy (nm) SPR Linewidth 80% (nm)
D12M-10-1064 10 67 1064 6.7 50 510 10 5.02E+03 1.81E+13 1.75 0.18% 1750 30.13 1.66E+09 3.32E+08 1022-1132 150
D12M-10-980 10 59 980 5.9 50 510 10 4.33E+03 2.09E+13 1.75 0.18% 1750 34.91 1.43E+09 2.86E+08 965-1022 150
D12M-10-950 10 55 950 5.5 50 510 10 4.09E+03 2.22E+13 1.75 0.18% 1750 37 1.35E+09 2.70E+08 925-965 150
D12M-10-900 10 50 900 5 50 510 10 3.68E+03 2.47E+13 1.75 0.18% 1750 41.11 1.22E+09 2.43E+08 875-925 150
D12M-10-850 10 45 850 4.5 50 510 10 3.27E+03 2.78E+13 1.75 0.18% 1750 46.25 1.08E+09 2.16E+08 829-875 100
D12M-10-808 10 41 808 4.1 50 510 10 2.93E+03 3.10E+13 1.75 0.18% 1750 51.68 9.68E+08 1.94E+08 794-829 75
D12M-10-780 10 38 780 3.8 50 510 10 2.70E+03 3.36E+13 1.75 0.18% 1750 56.06 8.92E+08 1.78E+08 765-794 65

 

  Ntracker Ntherapy
In batch size variation (10nm) < 10% CV < 10% CV
Shape monodispersity >95% nanorods >95% nanorods
Surface charge (zeta) 0 mV Amine +25mV, Carboxyl -5mV typ
pH 7.4 7.4
Residual Chemicals Trace Trace
Toxicity None None
Buffer PBS PBS

 

SPR = Longitudinal SPR peak
LSPR = Lower SPR peak
Shape monodispersity (% rods) > 95%
Aspect ratio variation = Peak SPR accuracy/96
All specs typical
This product is delivered in PBS and is radiation sterilized
Exact loading values are calculated
Exact values are measured for each batch

 

 

 

 

 

Part # Diameter (nm) Length (nm) Peak SPR Wave (nm) Aspect Ratio OD SPR (AU) Peak LSPR Wave (nm) OD LSPR (AU) Nanorod Vol (nm3) Nanorods /mL Wt. conc (mg/ml) Wt. % PPM Molarity (nM) SPR Molar Ext. (M-1cm-1) LSPR Molar Ext. (M-1cm-1) Peak SPR accuracy (nm) SPR Linewidth 80% (nm)
D12-10-1064 10 67 1064 6.7 50 510 10 5.02E+03 1.81E+13 1.75 0.18% 1750 30.13 1.66E+09 3.32E+08 1022-1132 150
D12-10-980 10 59 980 5.9 50 510 10 4.33E+03 2.09E+13 1.75 0.18% 1750 34.91 1.43E+09 2.86E+08 965-1022 150
D12-10-950 10 55 950 5.5 50 510 10 4.09E+03 2.22E+13 1.75 0.18% 1750 37 1.35E+09 2.70E+08 925-965 150
D12-10-900 10 50 900 5 50 510 10 3.68E+03 2.47E+13 1.75 0.18% 1750 41.11 1.22E+09 2.43E+08 875-925 150
D12-10-850 10 45 850 4.5 50 510 10 3.27E+03 2.78E+13 1.75 0.18% 1750 46.25 1.08E+09 2.16E+08 829-875 100
D12-10-808 10 41 808 4.1 50 510 10 2.93E+03 3.10E+13 1.75 0.18% 1750 51.68 9.68E+08 1.94E+08 794-829 75
D12-10-780 10 38 780 3.8 50 510 10 2.70E+03 3.36E+13 1.75 0.18% 1750 56.06 8.92E+08 1.78E+08 765-794 65

 

  Ntracker Ntherapy
In batch size variation (10nm) < 10% CV < 10% CV
Shape monodispersity >95% nanorods >95% nanorods
Surface charge (zeta) 0 mV Amine +25mV, Carboxyl -5mV typ
pH 7.4 7.4
Residual Chemicals Trace Trace
Toxicity None None
Buffer PBS PBS

 

SPR = Longitudinal SPR peak
LSPR = Lower SPR peak
Shape monodispersity (% rods) > 95%
Aspect ratio variation = Peak SPR accuracy/96
All specs typical
This product is delivered in PBS and is radiation sterilized
Exact loading values are calculated
Exact values are measured for each batch

 

 

 

 

 

Part #  Diam (nm) Length (nm) Peak SPR Wave (nm) Ex/Em (nm) Wt. conc (mg/ml) (10-3) Wt. % PPM Molarity (pM) Spectrally Similar Dyes
D16-10-1064 10 67 1064 777/794 1750.0 0.1750% 1750 32.9 IRDye 800
D16-10-980 10 59 980 777/794 1750.0 0.1750% 1750 38.6 IRDye 800
D16-10-850 10 45 850 777/794 1750.0 0.1750% 1750 53.0 IRDye 800
D16-10-808 10 41 808 777/794 1750.0 0.1750% 1750 60.3 IRDye 800
D16-10-780 10 38 780 754/776 1750.0 0.1750% 1750 66.4 Alexa Fluor 750

 

 

 

 

 

Functionalized Nanorod Block Invitro

 

Functionalized gold nanoparticle with Nanopartz™ Ntherapy covalently bonded polymer. Thickness of polymer is less than the size variablity of the gold nanoparticle.

 

Conjugations (Ordering Abbreviation)

 

A33scFv
Chitosan
anti-EGFR
DNA
oligos
Glutathione
Folate
CD33
CD24
CD45
EPCAM
Doxorubicin
T-Cells
anti-CD4
Polyethylenimine (PEI)
Polystyrene

 

A33scFv single-chain antibody selective for colorectal carcinoma cells and used as probes Kirui, D. K., Krishnan, S., Strickland, A. D. and Batt, C. A. , PAA-Derived Gold Nanorods for Cellular Targeting and Photothermal Therapy. Macromolecular Bioscience, n/a. doi: 10.1002/mabi.201100050
Chitosan Multiple thiol/oleyl groups on the polymer backbone introduced multiple anchoring points to the nanoparticle surface and improved the colloidal stability.The primary amine groups on the polymer backbone gave rise to further functionalization possibilities. Erathodiyil Nandanan, Nikhil R. Jana, Jackie Y. Ying  Advanced Materials 2008, 20, 2068–2073
anti-EGFR NRs are functionalized with anti-EGFR antibodies for specific binding to EGFR-positive human oral cancer cells. After exposure to a beam of focused NIR light, the cancer cells were destroyed without affecting the normal cells  Plasmonic photo-thermal therapy (PPTT) Xiaohua Huanga, Mostafa A. El-Sayed Alexandria Journal of Medicine Volume 47, Issue 1, March 2011, Pages 1–9
DNA  NIR irradiation of nanorod–EGFP DNA conjugates had been performed in HeLa cells, the expression of
EGFP in cells was detected at the irradiated spot after NIR exposure at 79 μJ/pulse for 1 min
H. Takahashi, Y. Niidome, S. Yamada, Controlled release of plasmid DNA from gold nanorods induced by pulsed near-infrared light, Chem. Commun. (Camb.) 17 (2005) 2247–2249
oligos selectively release multiple DNA oligonucleotides.with two different DNA oligonucleotides to short and long gold nanorods aspect ratio of t 4.0 and 5.4, corresponding to longitudinal plasmon resonances with light at 800 and 1100 nm respectively irradiated with a laser at the wavelength of 800 nm, only the short gold nanorods were melted but not the long ones. Alternatively, when a laser at the wavelength of 1100 nm was used to irradiate the mixture, the long rods transformed to spherical shapes but not the short ones. A. Wijaya, S.B. Schaffer, I.G. Pallares, K. Hamad-Schifferli, Selective release of
multiple DNA oligonucleotides from gold nanorods, ACS Nano 3 (1) (2008) 80–86.
Glutathione
Folate Conjugates of folic acid with gold nanoparticle could have an important role for folate receptor-targeted
drug delivery or targeted therapy in the future
R. Bhattacharya, C.R. Patra, A. Earl, S. Wang, A. Katarya, L. Lu, J.N. Kizhakkedathu,
M.J. Yaszemski, P.R. Greipp, D. Mukhopadhyay, P. Mukherjee, Attaching folic acid
on gold nanoparticles using noncovalent interaction via different polyethylene
glycol backbones and targeting of cancer cells, Nanomedicine 3 (3) (2007)
224–238.
CD33
CD24
CD45
EPCAM
Doxorubicin
T-Cells Improves cellular uptake invivo [PDF] T cells enhance gold nanoparticle delivery to tumors in vivo LC Kennedy, AS Bear, JK Young, NA Lewinski… - Nanoscale Research …, 2011
anti-CD4
Polyethylenimine (PEI)
Polystyrene

 

 

 

 

 

 

Fluorophore Type Excitation (nm) Emission (nm) Spectrally Similar Dyes
800 788 808 IRDye 800
750 750 773 Alexa Fluor 750

 

 

 

Composition

These polymer coated gold nanorods are shipped in PBS with no measurable residual chemicals. This product is radiation sterilized and is ready for injection.

Custom Formulation

Popular CW laser wavelengths are available (780, 808, 850, 980, and 1064nm).  Other sizes are special order.  Please contact us.

Quantity

This product is available in 1mL and larger but in two different concentrations. The lower concentration is suited for mice, while the higher concentration is suitable for companion animals. For mice, the 1mL injection is suited for 5 injections. For orders larger than 100mL, or for orders amounting over 500mL per annum, please contact sales for quantity pricing.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.

Conjugation

This product comes coated with a proprietary polymer to increase circulation times. Ntracker™ contains a non-reactive methyl termination. Ntherapy™ contains many choices for reactive terminations. Many popular in vivo conjugations are available.

Introductory Kits

Unfortunately there are no kits available for this product at this time.

Shelf Life/Storage Temperature

This product is guaranteed for one year and may be stored at room temperature.

Toxicity

These products are non cytotoxic.

Sterilization

This product is sterilized.

Certifications

This product is manufactured using our audited ISO 9000/2001 quality control system. Every order comes with a Certification of Analysis that includes the following information. We use NIST traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for gold mass measurements

TEM (Phillips CM-100 100KV) for sizing

Ntracker™ is based on extensive research in laboratory, preclinical, toxicology, and more recently clinical trials. The technology is based on patented, patent pending, and proprietary methods. Nanopartz™ has the capacity for up to 1kg of Ntracker™product per day in its audited ISO 9000 facility. Ntherapy™ offers the same technology as Ntracker™ with the added advantage of popular in vivo conjugations and customer specified oligo and antibody choices.

This product has been extensively tested in mice and companion animals.

Photoacoustic Images are provided by our partner Visualsonics Inc.

VisualSonics is the world leader in real-time, in vivo, high-resolution, micro-imaging systems, providing modalities specifically designed for preclinical research. VisualSonics has commercialized Vevo LAZR Technology, a state-of-the-art photoacoustic imaging system with inherent coregistration and capabilities for imaging gold nanorods in vivo. "Listen to the Light" - Photoacoustic imaging with the new Vevo LAZR System.

http://www.visualsonics.com/photoacoustics

Shallow-tissue modalities

Optical coherence tomography (OCT) [http://www.ncbi.nlm.nih.gov/pubmed/7585229]

OCT captures three-dimensional images from optical scattering media (e.g., biological tissue), and it sometimes can provide sub-micrometer resolution. However, the imaging depth in OCT is limited by optical scattering rather than absorption because scattering tends to attenuate and randomize the light. Depending on the wavelength of light, this technique can achieve imaging depths of up to 2 mm in most tissues. This technique has been used clinically for some applications such as eye examination and has been tested in vivo and ex vivo for cancer diagnosis. In order to generate sufficient contrast, the imaging agents for this modality need to have large scattering cross sections.

Photoacoustic tomography (PAT) [http://www.ncbi.nlm.nih.gov/pubmed/20049803]

PAT is a hybrid imaging modality that provides strong optical absorption contrast and high ultrasonic resolution. Because the spatial resolution beyond one optical transport mean free path (~1 mm) is determined by ultrasonic parameters, the maximum imaging depth and resolution of PAT are scalable when diffusive photons are available. One can greatly increase the penetration depth of PAT with near-infrared light because the optical absorption of hemoglobin and scattering of tissues are weak in this regime. Therefore, a proper combination of PAT with the right contrast agent can accurately detect and diagnose tumors. As in the case of OCT, the imaging depth depends on the wavelength of light, but the imaging depth (~30 mm) is higher than OCT. This modality is currently being evaluated in vivo. Additionally, contrast agents for PAT need to have large absorption cross sections.

Two-photon microscopy [http://www.ncbi.nlm.nih.gov/pubmed/2321027]

Two-photon microscopy is a fluorescence-based technique that offers images of living tissue up to ~1 mm in depth. It usually uses red-shifted light to minimize scattering in the tissue, and the background signal is strongly suppressed owing to multiphoton absorption. It is being tested in vivo. Recently, Nguyen and colleagues reported that surgery with molecular fluorescence imaging can be efficient for complete removal of tumors [http://www.ncbi.nlm.nih.gov/pubmed/20160097]. The results might suggest a breakthrough in the application of two-photon microscopy for molecular imaging to overcome the disadvantage of imaging depth.

Surface-enhanced Raman spectroscopy (SERS) imaging [http://www.ncbi.nlm.nih.gov/pubmed/9027306]

SERS utilizes the enhancement of Raman scattering by molecules adsorbed on surfaces of metal NPs. The increment can be as much as 10^14–10^15, hence Raman-active dyes placed on the surface of gold and silver colloids will exhibit greatly amplified Raman signals. The ability of gold colloids to easily conjugate with targeting ligands enables the detection of tumors in vivo using this technique [http://www.ncbi.nlm.nih.gov/pubmed/18157119, http://www.ncbi.nlm.nih.gov/pubmed/19666578]. 

 

 

 

  Nanopartz™ Ntracker™ Other Technologies
Circulation Time Long Low
Toxicity None Broad
Photothermal efficiency Highest recorded Low
Imaging potential Yes Very Limited
Drug Delivery potential Yes Very Limited
Tumor Loading High Low

 

 

 

  • Covalent bonds insure specificity, stability, long shelf life
  • Buffer Stability - stable from pH 4-9
  • No sodium azide
  • No BSA
  • Polymer coating insures no aggregation in high salts, reduced nonspecific binding
  • Stable
  • Well Characterized
  • Customer can select buffer
  • Customer can select gold nanoparticle type, size and/or SPR
  • Loading of all ligands is optimized
  • Customer can focus on research and not on Nanopartz expertise
  • Quick turnaround

 

 

 

"We have looked at many different gold nanoparticles samples from Nanopartz including spheres, rods, and microrods using single particle spectroscopy techniques and are extremely happy with the quality of the samples and the service provided by Nanopartz."

Stephan Link, PhD
Assistant Professor of Chemistry
Rice University

 

Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes

KH Song, C Kim, K Maslov, LV Wang - European journal of radiology, 2009 - Elsevier
... As lymph node tracers, gold nanorods (Nanopartz Inc.) were injected on a left forepaw pad in
the amount of 0.1 ml at a 979 ... Noninvasive in vivo PA SLN mapping with gold nanorods has been
successfully accomplished in a rat model. ... 3A was scanned with the PA imaging system ...
 

Real-time four-dimensional optical-resolution photoacoustic microscopy with Au nanoparticle-assisted subdiffraction-limit resolution

B Rao, K Maslov, A Danielli, R Chen, KK Shung… - Optics …, 2011 - osapublishing.org
... lateral resolution by imaging Au nanowire particles (product number 50-30-6000, 30 by 6000nm,
Nanopartz, Inc ... The high imaging speed makes this cellular imaging sys- tem suitable for
demanding dynamic cellular imaging ap- plications, such as in vivo flow cytometry ...
 

[HTML] Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model

PH Wang, HL Liu, PH Hsu, CY Lin… - … of biomedical optics, 2012 - spiedigitallibrary.org
 

[HTML] Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source

AF Bagley, S Hill, GS Rogers, SN Bhatia - ACS nano, 2013 - ncbi.nlm.nih.gov
... 16,17 Briefly, 41 nm × 10 nm cetyltrimethylammonium (CTAB)-coated GNRs (Nanopartz) were
concentrated ∼100-fold by ... In Vivo Quantification of Cargo. ... tumors were harvested and AS750
fluorescence within whole tumors was imaged on an NIR imaging system (LICOR ...
 

24-MHz scanner for optoacoustic imaging of skin and burn

L Vionnet, J Gâteau, M Schwarz… - … on medical imaging, 2014 - ieeexplore.ieee.org
... D. In Vivo Experiments The in vivo imaging capability of the system was demon- strated on ... Imaging
of the CD-1 mouse (mouse 1) leg was performed targeting endogenous contrast (hemoglobin ...
peak absorption at 800 nm (5e12 gold- nanorods in 100 L, Nanopartz Inc., Loveland ...

Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography

E Herzog, A Taruttis, N Beziere, AA Lutich, D Razansky… - Radiology, 2012 - pubs.rsna.org
... Gold nanorods (AuNR-M; Nanopartz, Loveland, Colo) with an optical absorption peak around ...
strong optical absorption, they are suitable contrast agents for optoacoustic imaging (25,26). ... of
hydrophilic methyl-polymers, which give the particles ultralong circulation times in vivo...
 

Near-infrared absorbing polymer nano-particle as a sensitive contrast agent for photo-acoustic imaging

H Aoki, M Nojiri, R Mukai, S Ito - Nanoscale, 2015 - pubs.rsc.org
... Water dispersed gold nano-rods (80 × 25 nm and 200 × 50 nm) were purchased from Nanopartz.
The PA intensity measurement was carried out using a home-built apparatus. ... For in vivo imaging,
normal nude mice (7 weeks old, male; BALB/c slc-nu/nu, Japan SLC) were used. ...
 

Pandia®

C Schoen, C London - Nanotechnology for Biomedical Imaging and … - Wiley Online Library
... This chapter demonstrates the results of imaging and treating sarcomas in companion animals. ...
There have been a number of studies conducted using Nanopartz AuNRs that have shown efficacy ...
of safety for the IV injection of PEG-coated AuNRs for in vivo photothermal cancer ...
 

In vivo Photothermal Optical Coherence Tomography of Gold Nanorods in the Mouse Eye

M Lapierre-Landry, AY Gordon… - Bio-Optics: Design and …, 2017 - osapublishing.org
... of the retina in vivo, which is a crucial step toward OCT-based molecular imaging in the eye. 2.
Methods 2.1 Gold nanorod synthesis: Polyethylene glycol (PEG)-coated gold nanorods (GNRs)
with peak absorption of 750 nm were purchased from Nanopartz (Loveland, USA). ...
 

Imaging the small animal cardiovascular system in real-time with multispectral optoacoustic tomography

A Taruttis, E Herzog, D Razansky… - … Ultrasound: Imaging …, 2011 - spiedigitallibrary.org
... an absorption peak in the near-infrared (Ntracker 30-PM-780, Nanopartz Inc., Loveland ... and
CD-1® Nude, Charles River Laboratories, Sulzfeld, Germany) imaged in vivo were anesthetized
using ketamine/xylazine and shaved (if necessary) prior to imaging in the ...