Self Assembled Monolayer, Alkane Thiol Functionalized Gold Nanoparticles - Nanopartz

Nanopartz Self Assembled Monolayer, Alkane Thiol Functionalized Gold Nanoparticles includes the full line of Monodisperse Accurate Spherical Gold Nanoparticles, Gold Nanorods, Microgold, and Gold Nanowire product familes functionalized with Self Assembled Monolayers (SAMs), or otherwise know as alkanethiols or molecular surface modifiers (MSMs). We offer the most popular covalent alkyl, functional, protected, ring and other self assembly materials on gold nanoparticles - from 1 carbon cysteamine to 16 carbon Mercaptohexadecanoic acid, and many in between - in all types of solvents. Upon conjugation, not only is every batch is completely purified, it is characterized including size, monodispersity, aggregation, residual chemicals, and concentration. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data.

‹

›

Product Specifications

Part #B11 Nanopartz Analytical Spherical Gold Nanoparticles @ 1mL

Part #	Diameter (nm)	Peak SPR Wavelength (nm)	NPS/ml	Molarity (pM)	Moles	Molar Ext. (M-1cm-1)	Absorption Molar Ext. (M-1cm-1)	Scattering Molar Ext. (M-1cm-1)	Size Dispersity %PDI	Size Accuracy (+/- nm)
B11-1.8	1.8	n/a	4.25E+16	7.10E+07	7.09E-08	7.05E+05	7.05E+05	0.00E+00	<35%	0.1
B11-2.2	2.2	n/a	2.33E+16	3.90E+07	3.88E-08	1.29E+06	1.29E+06	0.00E+00	<25%	0.1
B11-3	3	n/a	9.19E+15	1.50E+07	1.53E-08	3.26E+06	3.26E+06	0.00E+00	<20%	0.1
B11-4	4	n/a	3.88E+15	6.50E+06	6.46E-09	7.74E+06	7.74E+06	0.00E+00	<20%	1
B11-5	5	512	1.99E+15	3.30E+06	3.31E-09	1.51E+07	1.51E+07	0.00E+00	<20%	2
B11-10	10	516	2.48E+14	4.10E+05	4.14E-10	1.21E+08	1.21E+08	0.00E+00	<15%	2
B11-15	15	518	7.35E+13	1.20E+05	1.23E-10	4.08E+08	4.08E+08	0.00E+00	<15%	2
B11-20	20	520	3.10E+13	5.20E+04	5.17E-11	9.67E+08	9.67E+08	0.00E+00	<10%	2
B11-25	25	521	1.59E+13	2.60E+04	2.65E-11	1.89E+09	1.89E+09	0.00E+00	<10%	2
B11-30	30	523	9.19E+12	1.50E+04	1.53E-11	3.26E+09	3.26E+09	0.00E+00	<6%	2
B11-35	35	526	5.79E+12	9.60E+03	9.65E-12	5.18E+09	5.18E+09	0.00E+00	<6%	2
B11-40	40	527	3.88E+12	6.50E+03	6.46E-12	7.74E+09	7.72E+09	2.24E+07	<4%	2
B11-45	45	529	2.72E+12	4.50E+03	4.54E-12	1.10E+10	1.08E+10	2.03E+08	<4%	2
B11-50	50	531	1.99E+12	3.30E+03	3.31E-12	1.51E+10	1.45E+10	5.88E+08	<4%	2
B11-55	55	533	1.49E+12	2.50E+03	2.49E-12	2.01E+10	1.88E+10	1.30E+09	<4%	2
B11-60	60	536	1.15E+12	1.90E+03	1.91E-12	2.61E+10	2.36E+10	2.48E+09	<4%	2
B11-65	65	539	9.04E+11	1.50E+03	1.51E-12	3.32E+10	2.89E+10	4.33E+09	<4%	2
B11-70	70	542	7.23E+11	1.20E+03	1.21E-12	4.15E+10	3.44E+10	7.09E+09	<4%	2
B11-75	75	545	5.88E+11	9.80E+02	9.80E-13	5.10E+10	4.00E+10	1.10E+10	<4%	2
B11-80	80	549	4.85E+11	8.10E+02	8.08E-13	6.19E+10	4.54E+10	1.65E+10	<4%	2
B11-85	85	553	4.04E+11	6.70E+02	6.73E-13	7.42E+10	5.03E+10	2.39E+10	<4%	2
B11-90	90	558	3.40E+11	5.70E+02	5.67E-13	8.81E+10	5.44E+10	3.37E+10	<4%	2
B11-95	95	563	2.89E+11	4.80E+02	4.82E-13	1.04E+11	5.72E+10	4.65E+10	<4%	2
B11-100	100	569	2.48E+11	4.10E+02	4.14E-13	1.21E+11	5.82E+10	6.27E+10	<4%	2
B11-150	150	612	7.35E+10	1.20E+02	1.23E-13	4.08E+11	0.00E+00	4.08E+11	<4%	10
B11-200	200	n/a	3.10E+10	5.20E+01	5.17E-14	9.67E+11	0.00E+00	9.67E+11	<4%	10
B11-500	500	n/a	1.99E+09	3.30E+00	3.31E-15	1.51E+13	0.00E+00	1.51E+13	<4%	50
B11-1000	1000	n/a	2.48E+08	4.10E-01	4.14E-16	1.21E+14	0.00E+00	1.21E+14	<4%	100
B11-1500	1500	n/a	7.35E+07	1.20E-01	1.23E-16	4.08E+14	0.00E+00	4.08E+14	<4%	100

Optical Density >= 50, 5 for sizes >=500nm

Wt conc = 2.5mg in 0.25mL volume typical

Wt % = 1%

ppm = 10000

%PDI = Std Dev/Size

See Tech Note TN801 for definition of terms and method of analysis

All specs typical. May vary batch to batch. Exact values are measured for each batch

Shape monodispersity (% spheres) > 99.9%

Solution default is 18MEG DI water

Residual Chemicals < 0.1%

Part #B12 Nanopartz Analytical Gold Nanorods @ 1mL

Part #	Diameter (nm)	Length (nm)	Peak SPR Wave (nm)	Aspect Ratio	OD SPR (AU)	Peak LSPR Wave (nm)	OD LSPR (AU)	Nanorods /mL	Wt. conc (ug/ml)	Wt. %	PPM	Molarity (nM)	Picomoles	SPR Molar Ext. (M-1cm-1)	LSPR Molar Ext. (M-1cm-1)	Peak SPR (nm)	SPR Linewidth 80% (nm)
B12-5-808	5	21	808	4.2	50	510	10	2.39E+14	1750	0.18%	1750	398.72	3.99E+02	1.25E+08	2.51E+07	794-829	100
B12-5-780	5	19	780	3.8	50	510	10	2.67E+14	1750	0.18%	1750	444.72	4.45E+02	1.12E+08	2.25E+07	765-794	100
B12-5-700	5	15	700	3	50	510	10	3.47E+14	1750	0.18%	1750	578.14	5.78E+02	8.65E+07	1.73E+07	675-725	100

B12-10-2100	10	175	2100	17.5	50	510	10	6.73E+12	1750	0.18%	1750	11.21	1.12E+01	4.46E+09	8.92E+08	1900-2300	300
B12-10-1400	10	102	1400	10.2	50	510	10	1.17E+13	1750	0.18%	1750	19.47	1.95E+01	2.57E+09	5.14E+08	1300-1500	150
B12-10-1200	10	81	1200	8.1	50	510	10	1.48E+13	1750	0.18%	1750	24.67	2.47E+01	2.03E+09	4.05E+08	1132-1300	150
B12-10-1064	10	67	1064	6.7	50	510	10	1.81E+13	1750	0.18%	1750	30.13	3.01E+01	1.66E+09	3.32E+08	1022-1132	150
B12-10-980	10	59	980	5.9	50	510	10	2.09E+13	1750	0.18%	1750	34.91	3.49E+01	1.43E+09	2.86E+08	965-1022	150
B12-10-950	10	55	950	5.5	50	510	10	2.22E+13	1750	0.18%	1750	37	3.70E+01	1.35E+09	2.70E+08	925-965	150
B12-10-900	10	50	900	5	50	510	10	2.47E+13	1750	0.18%	1750	41.11	4.11E+01	1.22E+09	2.43E+08	875-925	150
B12-10-850	10	45	850	4.5	50	510	10	2.78E+13	1750	0.18%	1750	46.25	4.63E+01	1.08E+09	2.16E+08	829-875	100
B12-10-808	10	41	808	4.1	50	510	10	3.10E+13	1750	0.18%	1750	51.68	5.17E+01	9.68E+08	1.94E+08	794-829	75
B12-10-780	10	38	780	3.8	50	510	10	3.36E+13	1750	0.18%	1750	56.06	5.61E+01	8.92E+08	1.78E+08	765-794	65
B12-10-750	10	35	750	3.5	50	510	10	3.70E+13	1750	0.18%	1750	61.67	6.17E+01	8.11E+08	1.62E+08	725-765	50
B12-10-700	10	29	700	2.9	50	510	10	4.44E+13	1750	0.18%	1750	74	7.40E+01	6.76E+08	1.35E+08	675-725	40
B12-10-650	10	24	650	2.4	50	510	10	5.55E+13	1750	0.18%	1750	92.5	9.25E+01	5.41E+08	1.08E+08	625-675	40
B12-10-600	10	19	600	1.9	50	510	10	7.40E+13	1750	0.18%	1750	123.34	1.23E+02	4.05E+08	8.11E+07	575-625	40

B12-25-1400	25	245	1400	9.8	50	514	15	1.12E+12	2500	0.25%	2500	1.86	1.86E+00	2.69E+10	8.06E+09	1232-1500	150
B12-25-1064	25	137	1064	5.5	50	514	15	2.05E+12	2500	0.25%	2500	3.42	3.42E+00	1.46E+10	4.38E+09	1022-1232	150
B12-25-980	25	119	980	4.8	50	514	15	2.39E+12	2500	0.25%	2500	3.98	3.98E+00	1.26E+10	3.77E+09	965-1022	150
B12-25-950	25	102	950	4.1	50	514	15	2.82E+12	2500	0.25%	2500	4.7	4.70E+00	1.06E+10	3.19E+09	925-965	150
B12-25-900	25	96	900	3.8	50	514	15	3.01E+12	2500	0.25%	2500	5.02	5.02E+00	9.95E+09	2.99E+09	875-925	150
B12-25-850	25	93	850	3.7	50	514	15	3.12E+12	2500	0.25%	2500	5.2	5.20E+00	9.61E+09	2.88E+09	829-875	150
B12-25-808	25	90	808	3.6	50	514	15	3.24E+12	2500	0.25%	2500	5.39	5.39E+00	9.27E+09	2.78E+09	794-829	150
B12-25-780	25	87	780	3.5	50	514	15	3.36E+12	2500	0.25%	2500	5.6	5.60E+00	8.93E+09	2.68E+09	765-794	150
B12-25-750	25	85	750	3.4	50	514	15	3.45E+12	2500	0.25%	2500	5.75	5.75E+00	8.70E+09	2.61E+09	725-765	65
B12-25-700	25	75	700	3	50	514	15	3.96E+12	2500	0.25%	2500	6.61	6.61E+00	7.57E+09	2.27E+09	675-725	60
B12-25-650	25	71	650	2.8	50	514	15	4.22E+12	2500	0.25%	2500	7.03	7.03E+00	7.11E+09	2.13E+09	625-675	60
B12-25-600	25	57	600	2.3	50	514	15	5.43E+12	2500	0.25%	2500	9.05	9.05E+00	5.52E+09	1.66E+09	575-625	60
B12-25-550	25	34	550	1.4	50	514	15	1.01E+13	2500	0.25%	2500	16.91	1.69E+01	2.96E+09	8.87E+08	525-575	60

B12-40-1064	40	208	850	5.2	50	520	20	5.30E+11	2500	0.25%	2500	0.88	8.84E-01	5.66E+10	2.26E+10	1022-1232	150
B12-40-980	40	180	850	4.5	50	520	20	6.19E+11	2500	0.25%	2500	1.03	1.03E+00	4.84E+10	1.94E+10	875-1022	150
B12-40-850	40	148	850	3.7	50	520	20	7.67E+11	2500	0.25%	2500	1.28	1.28E+00	3.91E+10	1.57E+10	829-875	150
B12-40-808	40	134	808	3.4	50	520	20	8.56E+11	2500	0.25%	2500	1.43	1.43E+00	3.51E+10	1.40E+10	794-829	150
B12-40-780	40	124	780	3.1	50	520	20	9.33E+11	2500	0.25%	2500	1.55	1.55E+00	3.22E+10	1.29E+10	765-794	150
B12-40-750	40	112	750	2.8	50	520	20	1.05E+12	2500	0.25%	2500	1.74	1.74E+00	2.87E+10	1.15E+10	725-765	150
B12-40-700	40	92	700	2.3	50	520	20	1.31E+12	2500	0.25%	2500	2.19	2.19E+00	2.29E+10	9.14E+09	675-725	60
B12-40-650	40	80	650	2	50	520	20	1.55E+12	2500	0.25%	2500	2.58	2.58E+00	1.94E+10	7.75E+09	625-675	60
B12-40-600	40	68	600	1.7	50	520	20	1.89E+12	2500	0.25%	2500	3.15	3.15E+00	1.59E+10	6.35E+09	575-625	60
B12-40-550	40	60	550	1.5	50	520	20	2.21E+12	2500	0.25%	2500	3.69	3.69E+00	1.36E+10	5.42E+09	525-575	60

B12-50-1064	50	245	1064	4.9	50	530	25	2.89E+11	2500	0.25%	2500	0.48	4.82E-01	1.04E+11	5.18E+10	980-1232	150
B12-50-808	50	145	808	2.9	50	530	25	5.15E+11	2500	0.25%	2500	0.86	8.58E-01	5.83E+10	2.91E+10	750-850	150
B12-50-700	50	110	700	2.2	50	530	25	7.08E+11	2500	0.25%	2500	1.18	1.18E+00	4.24E+10	2.12E+10	650-750	150
B12-50-600	50	100	600	2	50	530	25	7.93E+11	2500	0.25%	2500	1.32	1.32E+00	3.78E+10	1.89E+10	550-650	150

B12-70-750	70	120	750	1.7	50	530	25	3.49E+11	2500	0.25%	2500	0.58	5.81E-01	8.60E+10	4.30E+10	700-800	150
B12-70-650	70	105	650	1.5	50	530	25	4.13E+11	2500	0.25%	2500	0.69	6.88E-01	7.27E+10	3.63E+10	600-700	150
B12-70-550	70	91	550	1.3	50	530	25	4.98E+11	2500	0.25%	2500	0.83	8.30E-01	6.02E+10	3.01E+10	500-600	150

Optical Density >= 200, volume = 0.25mL

All specs typical. May vary batch to batch. Exact values are measured for each batch

Solution default is 18MEG DI water

Residual Chemicals < 0.1%

Part #B13 Nanopartz Analytical Microgold @ 1mL

Part #	Diameter (nm)	Length (nm)	Aspect Ratio	Peak SPR Wave (nm)	SPR OD (1cm)	Microgold /mL	moles	Wt. conc (ug/ml)	Wt. %	PPM	Molarity (pM)	SPR Molar Ext. (M-1cm-1)
B13-500	75	500	6.7	510	0.25	6.18E+09	1.03E-14	250	0.03%	250	10.3	2.43E+07
B13-1000	100	1000	10	510	0.25	1.71E+09	2.85E-15	250	0.03%	250	2.85	8.78E+07

SPR = Transverse SPR peak

Longitudinal has no SPR peak

Shape monodispersity (% rods) > 95%

Size variation +/-10% (both dimensions)

Part #B14 Nanopartz Analytical Gold Nanowires @ 1mL

Part #	Diameter (nm)	Length (nm)	Aspect Ratio	Peak SPR Wave (nm)	Nanowires Vol (nm3)	Nanowires /mL	Wt. conc (ug/ml)	Wt. %	PPM	Molarity (pM)	SPR Molar Ext. (M-1cm-1)
B14-1000	75	1000	13	510	4.31E+06	3.01E+09	250	0.03%	250	5.02	9.96E+06
B14-2000	75	2000	27	510	8.72E+06	1.49E+09	250	0.03%	250	2.48	2.02E+07
B14-4000	75	4000	53	510	1.76E+07	7.39E+08	250	0.03%	250	1.23	4.06E+07
B14-6000	75	6000	80	510	2.64E+07	4.91E+08	250	0.03%	250	0.82	6.10E+07
B14-10000	75	10000	133	510	4.40E+07	2.94E+08	250	0.03%	250	0.49	1.02E+08
B14-20000	100	20000	200	510	1.57E+08	8.27E+07	250	0.03%	250	0.14	3.63E+08
B14-40000	140	40000	286	510	6.15E+08	2.11E+07	250	0.03%	250	0.04	1.42E+09

SPR = Transverse SPR peak

Longitudinal has no SPR peak

Shape monodispersity (% rods) > 95%

Size variation +/-10% (both dimensions)

Functionalizations

Alkanethiol Functionalized Gold Nanorods

Molecular Surface Modifier	Thiol Type	Molecular Formula
1-Decanethiol	Alkyl Thiols	C10H22S
1-Dodecanethiol	Alkyl Thiols	C12H26S
1-Hexadecanethiol	Alkyl Thiols	C16H34S
1-Octadecanethiol	Alkyl Thiols	C18H38S
1-Octanethiol	Alkyl Thiols	C8H18S
(11-Mercaptoundecyl)-N,N,N-trimethylammonium bromide	Functional Thiols	C14H32BrNS
11-Azido-1-undecanethiol	Functional Thiols	C11H23SN3
11-Mercapto-1-undecanol	Functional Thiols	C11H24OS
11-Mercaptoundecanoic acid	Functional Thiols	C11H22O2S
11-Mercaptoundecylhydroquinone	Functional Thiols	C17H28O2S
12-Mercaptododecanoic acid	Functional Thiols	C12H24O2S
12-Mercaptododecanoic acid NHS ester	Functional Thiols	C16H27NO4S
16-Mercaptohexadecanoic acid	Functional Thiols	C16H32O2S
3-Amino-1-propanethiol hydrochloride	Functional Thiols	C3H9NS · HCl
6-Amino-1-hexanethiol hydrochloride	Functional Thiols	C6H15NS · HCl
6-Mercapto-1-hexanol	Functional Thiols	C6H14OS
6-Mercaptohexanoic acid	Functional Thiols	C6H12O2S
1-Adamantanethiol	Ring Thiols	C10H16S
4-Mercaptobenzoic acid	Ring Thiols	C7H6O2S

	Loading Range (nm2)		Charge (mV)
	Smaller particles	Larger particles	Smaller particles	Larger particles

SAMs	5	4	-27	-12

Properties, Tech Notes, SDS, Storage and Handling

Details

Composition

These nanoparticles are shipped in 18MEG DI water (default solution) and a number of other solvents. Not all gold nanoparticle/SAM combinations are soluble in all solvents. Please contact us if you have any questions.

Custom Formulation

Please contact us.

Quantity

This product is available in 0.25mL volumes and larger.

Introductory Kits

Please contact us.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays except for dried particles. Saturday shipping available for extra charge.

Functionalization

This product comes with a number of different covalent options.

Shelf Life/Storage Temperature

This product is guaranteed for three months and should be stored at 4 °C after opening. Care must be taken to only use sterile glassware when working with this product. Please note the SAM functionalized gold nanoparticles are manufactured to the customer request. The stability is based on the combination of the SAM ligand and the gold nanoparticle size. Because we don't have any ability to change this (i.e. adding other ligands, buffers, etc.), the stability is based on that combination. The product delivered is the SAM functionalized gold nanoparticle. The UV VIS may change due to that combinational stability, but it is the product ordered. We do not spec the UV VIS as part of that product. Please contact us if you need more information about your specific needs.

Toxicity

The product toxicity is based on the solvent chosen.

Certifications

Every order comes with a Certification of Analysis that includes the following information. We use calibration traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for gold mass measurements

TEM (Phillips CM-100 100KV) for sizing

UV VIS

Tech Notes, SDS, S/H

TN602 Storage and Handling

TN801 UV VIS to Determine Size and Concentration

SDS Part # B

Sole Source Advantages

Gold Nanorods Characteristics

FAQz, Testimonials, Publications

FAQz

How much thickness does the SAMs add?

Typically 0.2nm per carbon length.

How do I determine the concentration of the product?

Simply divide the number of nanoparticles (nps) found on the included COA by the amount of solution you add.

Why do you sell your rods as OD-mLs and what does this mean?

This is because unlike spherical gold nanoparticles, the conversion from OD to mg is not linear with nanorod diameter. Consequently, for the same OD, the weight of the nanorods increases with diameter. 50 OD-mLs means that if you resuspend the material in 1mL of solvent, you will have an absorption of OD50 through a 1mL optical path.

Do all nanoparticles with all SAMs work in all solvents?

No. There are many limitations. We request you contact us first if you are unsure.

What is the shelf life if I never open the package and keep refrigerated?

Many of these products need to be used right away. We offer a shelf life of 30 days.

Should I store in the refrigerator?

Yes.

How do you size your gold nanoparticles? Does the size include the capping agent?

We use three methods to specify our gold nanoparticles; TEM, UV VIS, and DLS. Each has its own advantages and disadvantages, and we use a weighted system to take advantage of each methods strengths. In the end, we place the strongest weight to the TEM method, particularly since we use samples sizes greater than 50 particles for each lot.

Do you really provide a TEM for my specific lot?

Yes, and not just for 5-10 particles, rather 50-100 are standard.

What is OD?

Optical Density (OD) is measured by UV-VIS. An Optical Density OD=1 corresponds to a transmission of 10% through a 1cm cuvette. Optical Density is a nice unit to use since Optical Densities correlate linearly to concentration. So an Optical Density of 1.2 is equal to 1.2 times the concentration of a gold nanoparticle solution that has an Optical Density of 1. We use OD and concentration interchangingly as it is easier to refer to a solution of OD=1 rather than 2.35e12 nanoparticles. For all spheres up to 200nm, OD=1 does refer to 0.05mg/mL.

What is PDI?

PDI refers to polydispersity index and is equal to the standard deviation of the particle sizes divided by the average size.

Will you provide me the loading for the reactive groups for my journal paper?

Yes

Will you provide me a Certificate of Analysis containing all the necessary information for my journal paper?

Yes.

Will you disclose details on how you manufacture the product?

Unfortunately no.

Can I choose any buffer?

That depends on the requested conjugation, but in general, yes. We will advise if we don't think that a particular buffer is optimal for a particular product.

Can you help me put together procedures to use the product?

Absolutely.

Can you perform these conjugations and still keep the nanorod SPR where I specify?

Yes.

Can you work with very short covalent ligands, like 4 carbon lengths and have the particles stable?

Yes!

Are all combinations of SAM ligands and gold nanoparticles stable in all solvents?

No. If there is a concern, please contact us prior to ordering to get our best suggestions. Please note the SAM functionalized gold nanoparticles are manufactured to the customer request. The stability is based on the combination of the SAM ligand and the gold nanoparticle size. Because we don't have any ability to change this (i.e. adding other ligands, buffers, etc.), the stability is based on that combination. The product delivered is the SAM functionalized gold nanoparticle. The UV VIS may change due to that combinational stability, but it is the product ordered. We do not spec the UV VIS as part of that product. Please contact us if you need more information about your specific needs.

Testimonials

"We were previously making our own gold nanoparticles using the commonly used technique of citrate reduction of Au(III). The colloids generated are broadly polydisperse, and we were concerned that our application of these particles in immuno-gold labeling of cells for optical coherence microscopy (OCM) would be utilizing only the large diameter tail of the distribution. We purchased the sampler package of NanoPartz gold spheres (30 nm, 50 nm, 70 nm, 90 nm) and examined each size carefully with dynamic light scattering, OCM, and spectrophotometry. Our measurements indicated diameters a couple nanometers larger than specifications (a result of measurements on the fully hydrated state?), and remarkable monodispersity - within specs. It is clear to us now that our early immuno-gold results were dominated by the largest diameter spheres of our early colloids. We are delighted by the NanoPartz monodisperse preparations and recommend them strongly!"

Dr. Richard C. Haskell
Professor of Physics & Director of Physics Clinic
Physics Department
Harvey Mudd College

"The scientists at Nanopartz have developed a line of colloidal gold nanorods with extremely high monodispersity in size, shape, and mass. The surfactant layer is highly stable and readily displaced for biofunctionalization. In every test, in vitro and in vivo, these materials have exceeded our expectations."

Geoffrey A. von Maltzahn
NSF and Whitaker Graduate Fellow
Harvard-MIT Division of Health Sciences and Technology
Laboratory for Multiscale Regenerative Technologies

Publications

High colloidal stability of gold nanorods coated with a peptide-ethylene glycol: Analysis by cyanide-mediated etching and nanoparticle tracking analysis

P Free, G Conger, W Siji, JB Zhang… - Colloids and Surfaces B: …, 2016 - Elsevier

... Ethylene glycol-derived alkanethiol, HS-(CH 2 ) 11 -EG 6 , Mw 468, was purchased from Prochimia
(ProChimia Surfaces Sp. ... 25 nm diameter, 49 nm length) and 808 nm λ max wavelength (23 nm
diameter, 85 nm length) gold nanorods were purchased from Nanopartz Inc. ...

Biofunctionalized gold nanoparticles for SPR-biosensor-based detection of CEA in blood plasma

T Špringer, J Homola - Analytical and bioanalytical chemistry, 2012 - Springer

... AuNPs of 30 nm functionalized with a mixture of carboxy-terminated and hydroxy-terminated
thiols were obtained from Nanopartz, USA, at a ... Carboxy-terminated [HS–C 11 –(EG) 6 –OCH
2 –COOH] and hydroxy-terminated [HS–C 11 –(EG) 4 –OH] alkanethiols were purchased ...

Nanobiosensor for detection and quantification of DNA sequences in degraded mixed meats

ME Ali, U Hashim, S Mustafa, YB Man… - Journal of …, 2011 - dl.acm.org

... 35]. The oligo was labeled with an alkanethiol at one end and a fluorescent dye,
tetramethyl-rhodamine (TMR), at the other. ... al. [35] and Nanopartz's technical note
[36] and were found to be 2.01 × 1011 NPS/μL and 335 nM. ...

Enhancing sensitivity of surface plasmon resonance biosensors by functionalized gold nanoparticles: size matters

T Špringer, ML Ermini, B Špačková… - Analytical …, 2014 - ACS Publications

... terminated [HS–(CH 2 ) 11 –EG 6 –OCH 2 –COOH] and hydroxy-terminated [HS–C 11 –EG 4
–OH] alkanethiols were purchased ... Gold Nanoparticles Spherical AuNPs covalently functionalized
with neutravidin via a 2 nm polymer bridge were purchased from Nanopartz Inc., USA ...

Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of cisplatin

J Li, SQ Yap, SL Yoong, TR Nayak, GW Chandra… - Carbon, 2012 - Elsevier

... It has been demonstrated that alkanethiols readily assemble as a monolayer on the surface of
gold [14], [15], [16], [17], [18], [19], [20], [21] and [22], which is facilitated by strong bonds between
gold and sulphur ... Spherical GNPs (4 nm diameter) were purchased from Nanopartz™. ...

[PDF] Immunoassay Test Strip for Microcystin-LR Detection

J Xu - 2010 - fau.digital.flvc.org

... Ab so rb a n ce wavelength Figure 3. Alkanethiols-AuNPs Figure 4. UV-Vis spectra of 20 nm and
5 nm colloidal gold The fluorescence spectra of colloidal were studied by Zhu and other ... 20 nm
colloidal gold (S01007B) was purchased from Nanopartz (Loveland, CO). 5 nm water ...

Multi‐Parametric Sensing Platforms Based on Nanoparticles

M Segev‐Bar, N Bachar, Y Wolf… - Advanced Materials …, 2017 - Wiley Online Library

... MCNPs thin films were made using 2 sets of nanoparticles: (a) a set of Au-NPs with fixed (Au)
core diamater but capped with a series of organic alkanethiols that have ... The baseline resistances
showed a clear dependency in the organic alkanethiol chain length and NP diameter ...

Single gold nanoparticle-based colorimetric detection of picomolar mercury ion with dark-field microscopy

X Liu, Z Wu, Q Zhang, W Zhao, C Zong… - Analytical chemistry, 2016 - ACS Publications

... Meanwhile, for oligopeptides, certain block units, such as Lys, have affinity for Hg 2+ . LODs
of this group vary between 26 nM and 20 μM. The third group includes alkanethiols and
derivatives of mercaptoaliphatic acid and urea with LODs of 0.5–100 nM. ...

Technology

Background

The manufacturing method for these nanoparticles are based on our proprietary method. Many alkanethiols require special solvents and purification methods to optimize loading. Most of our synthesis require many days for correct functionalization, purification, and QA. With proper environments, SAM densities of over 5/nm2 can be achieved resulting in very stable gold nanoparticle products.

Technology Comparison

	*Nanopartz™ Analytical* Gold Nanoparticles**
Stability (salt,pH,chemicals)	Variable
Monovalent	No
Nonspecific binding	Yes
Sterilization	Yes