All About Gold Nanoparticles
Definition, Properties and Applications
Gold nanoparticles are a type of nanomaterial with unique properties that make them valuable for various applications in different fields, particularly in biomedicine. Gold nanoparticles have gained significant attention due to their biocompatibility, chemical stability, and unique optical properties (Folorunso et al., 2019). These nanoparticles have been widely explored for their potential applications in biomedical areas, including diagnostic imaging, biosensing, drug delivery, and photothermal and photodynamic therapies (Wani, 2018). Additionally, gold nanoparticles have been demonstrated to be safe with low toxicity compared to other metal nanoparticles, making them suitable for various biomedical applications (Torres-Ortiz et al., 2023).
The properties of gold nanoparticles, such as their size and surface chemistry, play a crucial role in determining their toxicity and biological interactions (Zhang et al., 2011). It has been reported that smaller gold nanoparticles, particularly those smaller than 5 nm, exhibit increased toxicity to certain cell types (Wu et al., 2022). However, the surface chemistry and physical dimensions of gold nanoparticles are also known to influence their toxicity, highlighting the importance of understanding these factors in biomedical applications (Zhang et al., 2011).
The synthesis of gold nanoparticles has been a subject of extensive research, with a focus on green synthesis methods using plant extracts and microorganisms (Thirunavukkarasu et al., 2020; Khan & A.S, 2016; Ramezani et al., 2008; Jagtap, 2019). These green synthesis methods offer a non-toxic and environmentally friendly approach to producing gold nanoparticles for various biomedical applications ("undefined", 2019). Furthermore, the unique properties of gold nanoparticles, such as their surface plasmon absorption and surface accessibility for functionalization, make them suitable for use in biosensors, drug delivery systems, and cancer treatment (Jagtap, 2019).
In the field of biomedicine, gold nanoparticles have been explored for their potential as contrast agents, delivery vehicles, and therapeutics (Matea et al., 2016). Their use as photothermal contrast agents for cancer therapy, particularly in the form of gold nanorods, has shown promise in preclinical studies (Near et al., 2013). Additionally, gold nanoparticles have been investigated for their antimicrobial activity, making them potential candidates for applications in infection control and treatment (Khan & A.S, 2016; P, 2019).
In conclusion, gold nanoparticles possess unique properties that make them highly valuable for a wide range of biomedical applications. Their biocompatibility, chemical stability, and tunable optical properties have positioned them as promising candidates for use in diagnostic imaging, drug delivery, cancer therapy, and biosensing. The synthesis of gold nanoparticles using green methods further enhances their potential for safe and effective biomedical applications.
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