• Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)
  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
  • Image of Nanopartz GNR labeled cell subsequently labeled with the live cell dye Calcein-AM, shown in red. From Motamedi 2011 BOE (2)5. NCBI Copyright Approval.
  • Two Photon Image of Nanopartz GNR labeled cells using an incident power of 0.7mW overlayed with corresponding transmitted light micrograph. From Motmaedi 2011 BOE(2)5. NCBI Copyright Approved.
  • Two photon image using low incident power of 1mW following intravenous injection of Nanopartz gold nanorods in Hamster Model showing blood vessels in the tissue. From Motamedi 2011 BOE (2) 5. NCBI Copyright Approved.
  • White light microscopy images of control tumor and GNS and Nanopartz Ntracker GNR injected mice. (Pink: cytoplasm stained with eosin, Dark Blue: nuclei stained with hematoxylin). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Tumor model (Green: cytoplasm stained with eosin, Yellow: GNSs and Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Nanopartz gold nanorod injected mice with nuclei staning (YOYO-1 iodide). Two photon IP image with FOV of 720x490um measured at the distance of approximately 100um inside the tumor edge. (Green: nuclei, Yellow: Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of Nanopartz gold nanorod injected mice with blood vessel staining (CD31 immunofluorescence staining). TPIP image with FOV of 790x520um. Red: blood vessels, Yellow: Nanopartz Ntracker Gold Nanorods. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of liver of Nanopartz Ntracker gold nanorod injected mice. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • In vivo imaging of single gold nanorods in mice ear blood vessels. Overlay of transmission image (light blue) and a single frame TPL image. Two single nanorods (red spots) are superimposed by a linescan (white). From Wei Nanomedicine (Lond). 2007 February 2(1) 125-132. NCBI Copyright Approval.
  • B Mode and photoacoustic images of subcutaneous tumor before and 2 minutes after a 200uL bolus of Nanopartz gold nanorods. Photoacoustic contrast in enhanced by gold nanorods in vasculature. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised spleen of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse spleen. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 970nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Gold nanorod contrast enhanced Optical Coherence Tomography images of a human breast carcinoma tissue sample. The sturcutral OCT image is presented in red, and the SOCT computed GNR density is presented in green.

Nanopartz™in vivo Gold Nanoparticles

Nanopartz™ gold nanoparticles for in vivo application include both the Ntracker™ and Ntherapy™ family of nanorods, along with customer defined oligo and antibody conjugated nanrods for in vivo applications. The Ntracker™ non reactive methyl terminated nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. Ntherapy™ nanorods come with similar hydrophilic polymers, but with terminal amine and carboxyl active groups, along with a number of custom popular in vivo targeting ligands. Ntherapy™ also provides an opportunity for the customer to define their own targeting ligands utilizing Nanopartz™ nanorod and polymer technologies. In this family, Nanopartz™ has the ability to covalently conjugate to specific antibody locations, thereby for example, leaving necessary primary amines exposed for optimum activity. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting. As opposed to other commercially available nanoparticles such as quantum dots, Nanopartz™ in vivo line of nanorods are completely non-toxic. Whereas Ntracker™ takes advantage of the Enhanced Permeability and Retention effect (EPR) for passive in vivo targeting, Ntherapy™ utilizes popular ligands for active targeting. This product line comes in a diameter of 10nm with SPRs matching all of the popular Near IR CW laser wavelengths; 780, 808, 850, 980, and 1064nm. Ntherapy™ offers options for oligo and customer detailed conjugations. Every batch is radiation sterilized in PBS, and comes with instructions for in vivomouse iv injection. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped next day for many ligands. This product comes in two concentrations, regular 1.75mg/mL, and highly concentrated 10mg/mL.

Nanopartz™ In Vivo Plasmonic Fluorophores™ are fluorophore decorated gold nanorods manufactured using multiple patent pending and proprietary methods that result in fluorophores that exhibit much higher intensities than conventional fluorophores, no photobleaching even under the highest laser intensities, with long circulation times in vivo. Peak fluorescence range from 780 to 1064nm utilizing the same nanorods and in vivo polymer used in our Ntracker and Ntherapy products.

Home » D- In Vivo Gold Nanoparticles » D- Conjugated Gold Nanoparticles for In Vivo
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Ntherapy
Ntherapy
Part# D12-(SPR)-(Conjugation)-(Wt. conc)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Price: $480.00
Ntherapy Custom Oligo
Ntherapy Custom Oligo
Part# D12L-(SPR)-(Oligo Sequence)-(Wt. conc); Oligo sequence up to 30BP
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Price: $750.00
Ntracker
Ntracker
Part# D12M-(SPR)-(Wt.conc)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Price: $480.00
Ntherapy Custom Conjugation
Ntherapy Custom Conjugation
Part# D12R-(SPR)-(Ligand)-(Wt. conc); This product is for quotation only.
Sterilization
Certified Sterilized
Endotoxin
Endotoxin Purified
Endotoxin Purified and Certified
Price: $0.00
In-Vivo Plasmonic Fluorophores
In-Vivo Plasmonic Fluorophores
Part # D16-(DIAM-SPR)-(CONJUGATION)-(OD-mLs)
Sterilization
Certified Sterilized (+$150.00)
Endotoxin
Endotoxin Purified and Certified (+$250.00)
Negative Control
0.1mL Nonreactive Methyl (+$100.00)
1mL Nonreactive Methyl (+$480.00)
Price: $480.00

 

 

 

 

Part # Diameter (nm) Peak SPR Wavelength (nm) Optical Density (1cm) NPS/ml Wt. conc (mg/ml) Wt. % PPM Molarity (pM) Molar Ext. (M-1cm-1) Absorption Molar Ext. (M-1cm-1) Scattering Molar Ext. (M-1cm-1) Size Dispersity %PDI Notes
D11-1.8 1.8 505-508 50 4.25E+16 2.5 0.25% 2500 7.10E+07 7.05E+05 7.05E+05 0.00E+00 <35% 1,3
D11-2.2 2.2 505-508 50 2.33E+16 2.5 0.25% 2500 3.90E+07 1.29E+06 1.29E+06 0.00E+00 <25% 1,3
D11-3 3 505-508 50 9.19E+15 2.5 0.25% 2500 1.50E+07 3.26E+06 3.26E+06 0.00E+00 <20% 1,3
D11-4 4 505-508 50 3.88E+15 2.5 0.25% 2500 6.50E+06 7.74E+06 7.74E+06 0.00E+00 <20% 1,3
D11-5 5 505-508 50 1.99E+15 2.5 0.25% 2500 3.30E+06 1.51E+07 1.51E+07 0.00E+00 <20% 2,3
D11-10 10 514-520 50 2.48E+14 2.5 0.25% 2500 4.10E+05 1.21E+08 1.21E+08 0.00E+00 <15% 2,3
D11-15 15 514-520 50 7.35E+13 2.5 0.25% 2500 1.20E+05 4.08E+08 4.08E+08 0.00E+00 <15% 2,3
D11-20 20 514-520 50 3.10E+13 2.5 0.25% 2500 5.20E+04 9.67E+08 9.67E+08 0.00E+00 <10% 2,3
D11-25 25 514-520 50 1.59E+13 2.5 0.25% 2500 2.60E+04 1.89E+09 1.89E+09 0.00E+00 <10% 2
D11-30 30 523 50 9.19E+12 2.5 0.25% 2500 1.50E+04 3.26E+09 3.26E+09 0.00E+00 <6% 2
D11-35 35 526 50 5.79E+12 2.5 0.25% 2500 9.60E+03 5.18E+09 5.18E+09 0.00E+00 <6% 2
D11-40 40 527 50 3.88E+12 2.5 0.25% 2500 6.50E+03 7.74E+09 7.72E+09 2.24E+07 <4% 2
D11-45 45 529 50 2.72E+12 2.5 0.25% 2500 4.50E+03 1.10E+10 1.08E+10 2.03E+08 <4% 2
D11-50 50 531 50 1.99E+12 2.5 0.25% 2500 3.30E+03 1.51E+10 1.45E+10 5.88E+08 <4% 2
D11-55 55 533 50 1.49E+12 2.5 0.25% 2500 2.50E+03 2.01E+10 1.88E+10 1.30E+09 <4% 2
D11-60 60 536 50 1.15E+12 2.5 0.25% 2500 1.90E+03 2.61E+10 2.36E+10 2.48E+09 <4% 2
D11-65 65 539 50 9.04E+11 2.5 0.25% 2500 1.50E+03 3.32E+10 2.89E+10 4.33E+09 <4% 2
D11-70 70 542 50 7.23E+11 2.5 0.25% 2500 1.20E+03 4.15E+10 3.44E+10 7.09E+09 <4% 2
D11-75 75 545 50 5.88E+11 2.5 0.25% 2500 9.80E+02 5.10E+10 4.00E+10 1.10E+10 <4% 2
D11-80 80 549 50 4.85E+11 2.5 0.25% 2500 8.10E+02 6.19E+10 4.54E+10 1.65E+10 <4% 2
D11-85 85 553 50 4.04E+11 2.5 0.25% 2500 6.70E+02 7.42E+10 5.03E+10 2.39E+10 <4% 2
D11-90 90 558 50 3.40E+11 2.5 0.25% 2500 5.70E+02 8.81E+10 5.44E+10 3.37E+10 <4% 2
D11-95 95 563 50 2.89E+11 2.5 0.25% 2500 4.80E+02 1.04E+11 5.72E+10 4.65E+10 <4% 2
D11-100 100 569 50 2.48E+11 2.5 0.25% 2500 4.10E+02 1.21E+11 5.82E+10 6.27E+10 <4% 2
D11-125 125 600 50 1.27E+11 2.5 0.25% 2500 2.10E+02 2.36E+11 1.53E+11 8.32E+10 <4% 2
D11-150 150 612 50 7.35E+10 2.5 0.25% 2500 1.20E+02 4.08E+11 2.64E+11 1.44E+11 <4% 2

 

  Notes:
1
Size accuracy +/- 0.1 nm
1
Capping agent is covalently bonded carboxyl
2
Size accuracy +/- 2 nm
3
Peak SPR does not determine size for d<20 nm
Vol is 1mL
%PDI = Std Dev/Size
See Tech Note TN801 for definition of terms and method of analysis
All specs typical. May vary batch to batch. Exact values are measured for each batch
OD >=50 for all sizes
Shape monodispersity (% spheres) > 99.9%
Solution is 18MEG DI water
Residual Chemicals < 0.1%

 

 

 

Part # Diameter (nm) Length (nm) Peak SPR Wave (nm) Aspect Ratio OD SPR (AU) Peak LSPR Wave (nm) OD LSPR (AU) Nanorod Vol (nm3) Nanorods /mL Wt. conc (mg/ml) Wt. % PPM Molarity (nM) SPR Molar Ext. (M-1cm-1) LSPR Molar Ext. (M-1cm-1) Peak SPR accuracy (nm) SPR Linewidth 80% (nm)
D12-10-2100 10 175 2100 17.5 5 510 1 1.35E+04 6.73E+11 0.175 0.02% 175 1.12 4.46E+09 8.92E+08 1900-2300 300
D12-10-1400 10 102 1400 10.2 5 510 1 7.77E+03 1.17E+12 0.175 0.02% 175 1.95 2.57E+09 5.14E+08 1300-1500 150
D12-10-1200 10 81 1200 8.1 5 510 1 6.13E+03 1.48E+12 0.175 0.02% 175 2.47 2.03E+09 4.05E+08 1132-1300 150
D12-10-1064 10 67 1064 6.7 50 510 10 5.02E+03 1.81E+13 1.75 0.18% 1750 30.13 1.66E+09 3.32E+08 1022-1132 150
D12-10-980 10 59 980 5.9 50 510 10 4.33E+03 2.09E+13 1.75 0.18% 1750 34.91 1.43E+09 2.86E+08 965-1022 150
D12-10-950 10 55 950 5.5 50 510 10 4.09E+03 2.22E+13 1.75 0.18% 1750 37 1.35E+09 2.70E+08 925-965 150
D12-10-900 10 50 900 5 50 510 10 3.68E+03 2.47E+13 1.75 0.18% 1750 41.11 1.22E+09 2.43E+08 875-925 150
D12-10-850 10 45 850 4.5 50 510 10 3.27E+03 2.78E+13 1.75 0.18% 1750 46.25 1.08E+09 2.16E+08 829-875 100
D12-10-808 10 41 808 4.1 50 510 10 2.93E+03 3.10E+13 1.75 0.18% 1750 51.68 9.68E+08 1.94E+08 794-829 75
D12-10-780 10 38 780 3.8 50 510 10 2.70E+03 3.36E+13 1.75 0.18% 1750 56.06 8.92E+08 1.78E+08 765-794 65
D12-10-750 10 35 750 3.5 50 510 10 2.45E+03 3.70E+13 1.75 0.18% 1750 61.67 8.11E+08 1.62E+08 725-765 50
D12-10-700 10 29 700 2.9 50 510 10 2.04E+03 4.44E+13 1.75 0.18% 1750 74 6.76E+08 1.35E+08 675-725 40
D12-10-650 10 24 650 2.4 50 510 10 1.64E+03 5.55E+13 1.75 0.18% 1750 92.5 5.41E+08 1.08E+08 625-675 40
D12-10-600 10 19 600 1.9 50 510 10 1.23E+03 7.40E+13 1.75 0.18% 1750 123.34 4.05E+08 8.11E+07 575-625 40
D12-25-1400 25 245 1400 9.8 5 514 1 1.16E+05 1.12E+11 0.25 0.03% 250 0.19 2.69E+10 5.37E+09 1232-1500 150
D12-25-1064 25 137 1064 5.5 5 514 1 6.31E+04 2.05E+11 0.25 0.03% 250 0.34 1.46E+10 2.92E+09 1022-1232 150
D12-25-980 25 119 980 4.8 50 514 10 5.43E+04 2.39E+12 2.5 0.25% 2500 3.98 1.26E+10 2.51E+09 965-1022 150
D12-25-950 25 102 950 4.1 50 514 10 4.60E+04 2.82E+12 2.5 0.25% 2500 4.7 1.06E+10 2.13E+09 925-965 150
D12-25-900 25 96 900 3.8 50 514 10 4.30E+04 3.01E+12 2.5 0.25% 2500 5.02 9.95E+09 1.99E+09 875-925 150
D12-25-850 25 93 850 3.7 50 514 10 4.15E+04 3.12E+12 2.5 0.25% 2500 5.2 9.61E+09 1.92E+09 829-875 150
D12-25-808 25 90 808 3.6 50 514 10 4.01E+04 3.24E+12 2.5 0.25% 2500 5.39 9.27E+09 1.85E+09 794-829 150
D12-25-780 25 87 780 3.5 50 514 10 3.86E+04 3.36E+12 2.5 0.25% 2500 5.6 8.93E+09 1.79E+09 765-794 150
D12-25-750 25 85 750 3.4 50 514 10 3.76E+04 3.45E+12 2.5 0.25% 2500 5.75 8.70E+09 1.74E+09 725-765 65
D12-25-700 25 75 700 3 50 514 10 3.27E+04 3.96E+12 2.5 0.25% 2500 6.61 7.57E+09 1.51E+09 675-725 60
D12-25-650 25 71 650 2.8 50 514 10 3.07E+04 4.22E+12 2.5 0.25% 2500 7.03 7.11E+09 1.42E+09 625-675 60
D12-25-600 25 57 600 2.3 50 514 10 2.39E+04 5.43E+12 2.5 0.25% 2500 9.05 5.52E+09 1.10E+09 575-625 60
D12-25-550 25 34 550 1.4 50 514 10 1.28E+04 1.01E+13 2.5 0.25% 2500 16.91 2.96E+09 5.91E+08 525-575 60
D12-40-850 40 148 850 3.7 50 520 10 1.69E+05 7.67E+11 2.5 0.25% 2500 1.28 3.91E+10 7.83E+09 829-875 60
D12-40-808 40 134 808 3.4 50 520 10 1.52E+05 8.56E+11 2.5 0.25% 2500 1.43 3.51E+10 7.01E+09 794-829 60
D12-40-780 40 124 780 3.1 50 520 10 1.39E+05 9.33E+11 2.5 0.25% 2500 1.55 3.22E+10 6.43E+09 765-794 60
D12-40-750 40 112 750 2.8 50 520 10 1.24E+05 1.05E+12 2.5 0.25% 2500 1.74 2.87E+10 5.73E+09 725-765 60
D12-40-700 40 92 700 2.3 50 520 10 9.88E+04 1.31E+12 2.5 0.25% 2500 2.19 2.29E+10 4.57E+09 675-725 60
D12-40-650 40 80 650 2 50 520 10 8.37E+04 1.55E+12 2.5 0.25% 2500 2.58 1.94E+10 3.87E+09 625-675 60
D12-40-600 40 68 600 1.7 50 520 10 6.87E+04 1.89E+12 2.5 0.25% 2500 3.15 1.59E+10 3.18E+09 575-625 60
D12-40-550 40 60 550 1.5 50 520 10 5.86E+04 2.21E+12 2.5 0.25% 2500 3.69 1.36E+10 2.71E+09 525-575 60
D12-50-800 50 145 800 2.9 50 530 10 2.52E+05 5.15E+11 2.5 0.25% 2500 0.86 5.83E+10 1.17E+10 750-825 60
D12-50-700 50 110 700 2.2 50 530 10 1.83E+05 7.08E+11 2.5 0.25% 2500 1.18 4.24E+10 8.48E+09 650-750 60
D12-50-600 50 100 600 2 50 530 10 1.64E+05 7.93E+11 2.5 0.25% 2500 1.32 3.78E+10 7.57E+09 550-650 60

 

 

 

 

Part #  Diam (nm) Long Size (nm) Peak SPR Wave (nm) Ex/Em (nm) Wt. conc (mg/ml) (10-3) Wt. % PPM Molarity (pM) Spectrally Similar Dyes
C16-10-1064 10 67 1064 777/794 1750.0 0.1750% 1750 32.9 IRDye 800
C16-10-980 10 59 980 777/794 1750.0 0.1750% 1750 38.6 IRDye 800
C16-10-850 10 45 850 777/794 1750.0 0.1750% 1750 53.0 IRDye 800
C16-10-808 10 41 808 777/794 1750.0 0.1750% 1750 60.3 IRDye 800
C16-10-780 10 38 780 754/776 1750.0 0.1750% 1750 66.4 Alexa Fluor 750
C16-25-800 25 99 800 777/794 2500.0 0.2500% 2500 5.8 IRDye 800
C16-25-750 25 86 750 754/776 2500.0 0.2500% 2500 7.0 Alexa Fluor 750
C16-25-680 25 68 680 692/712 2500.0 0.2500% 2500 9.9 Alexa Fluor 680, Cy5.5
C16-25-650 25 60 650 652/672 2500.0 0.2500% 2500 12.0 Alexa Fluor 647, Cy5
C16-25-633 25 56 633 638/658 2500.0 0.2500% 2500 13.6 Alexa Fluor 633
C16-25-600 25 46 594 593/618 2500.0 0.2500% 2500 19.9 Alexa Fluor 594, Texas Red
C16-25-550 25 33 546 562/576 2500.0 0.2500% 2500 45.6 Alexa Fluor 546, Alexa Fluor 555

 

 

 

 

 

Functionalized Nanorod Block Invitro

 

Functionalized gold nanoparticle with Nanopartz™ Ntherapy covalently bonded polymer. Thickness of polymer is less than the size variablity of the gold nanoparticle.

 

Conjugations (Ordering Abbreviation)

 

A33scFv
Chitosan
anti-EGFR
DNA
oligos
Glutathione
Folate
CD33
CD24
CD45
EPCAM
Doxorubicin
T-Cells
anti-CD4
Polyethylenimine (PEI)
Polystyrene

 

A33scFv single-chain antibody selective for colorectal carcinoma cells and used as probes Kirui, D. K., Krishnan, S., Strickland, A. D. and Batt, C. A. , PAA-Derived Gold Nanorods for Cellular Targeting and Photothermal Therapy. Macromolecular Bioscience, n/a. doi: 10.1002/mabi.201100050
Chitosan Multiple thiol/oleyl groups on the polymer backbone introduced multiple anchoring points to the nanoparticle surface and improved the colloidal stability.The primary amine groups on the polymer backbone gave rise to further functionalization possibilities. Erathodiyil Nandanan, Nikhil R. Jana, Jackie Y. Ying  Advanced Materials 2008, 20, 2068–2073
anti-EGFR NRs are functionalized with anti-EGFR antibodies for specific binding to EGFR-positive human oral cancer cells. After exposure to a beam of focused NIR light, the cancer cells were destroyed without affecting the normal cells  Plasmonic photo-thermal therapy (PPTT) Xiaohua Huanga, Mostafa A. El-Sayed Alexandria Journal of Medicine Volume 47, Issue 1, March 2011, Pages 1–9
DNA  NIR irradiation of nanorod–EGFP DNA conjugates had been performed in HeLa cells, the expression of
EGFP in cells was detected at the irradiated spot after NIR exposure at 79 μJ/pulse for 1 min
H. Takahashi, Y. Niidome, S. Yamada, Controlled release of plasmid DNA from gold nanorods induced by pulsed near-infrared light, Chem. Commun. (Camb.) 17 (2005) 2247–2249
oligos selectively release multiple DNA oligonucleotides.with two different DNA oligonucleotides to short and long gold nanorods aspect ratio of t 4.0 and 5.4, corresponding to longitudinal plasmon resonances with light at 800 and 1100 nm respectively irradiated with a laser at the wavelength of 800 nm, only the short gold nanorods were melted but not the long ones. Alternatively, when a laser at the wavelength of 1100 nm was used to irradiate the mixture, the long rods transformed to spherical shapes but not the short ones. A. Wijaya, S.B. Schaffer, I.G. Pallares, K. Hamad-Schifferli, Selective release of
multiple DNA oligonucleotides from gold nanorods, ACS Nano 3 (1) (2008) 80–86.
Glutathione
Folate Conjugates of folic acid with gold nanoparticle could have an important role for folate receptor-targeted
drug delivery or targeted therapy in the future
R. Bhattacharya, C.R. Patra, A. Earl, S. Wang, A. Katarya, L. Lu, J.N. Kizhakkedathu,
M.J. Yaszemski, P.R. Greipp, D. Mukhopadhyay, P. Mukherjee, Attaching folic acid
on gold nanoparticles using noncovalent interaction via different polyethylene
glycol backbones and targeting of cancer cells, Nanomedicine 3 (3) (2007)
224–238.
CD33
CD24
CD45
EPCAM
Doxorubicin
T-Cells Improves cellular uptake invivo [PDF] T cells enhance gold nanoparticle delivery to tumors in vivo LC Kennedy, AS Bear, JK Young, NA Lewinski… - Nanoscale Research …, 2011
anti-CD4
Polyethylenimine (PEI)
Polystyrene

 

 

 

 

 

 

Fluorophore Type Excitation (nm) Emission (nm) Spectrally Similar Dyes
800 788 808 IRDye 800
750 750 773 Alexa Fluor 750
680 673 707 Alexa Fluor 680, Cy5.5
650 646 662 Alexa Fluor 647, Cy5
633 638 658 Alexa Fluor 633
600 591 604 Alexa Fluor 594, Texas Red
550 555 570 Alexa Fluor 546, Alexa Fluor 555
532 533 556  
514 520 540  
488 494 518 FITC, Alexa Fluor 488

 

 

 

Composition

These polymer coated gold nanorods are shipped in PBS with no measurable residual chemicals. This product is radiation sterilized and is ready for injection.

Custom Formulation

Popular CW laser wavelengths are available (780, 808, 850, 980, and 1064nm).  Other sizes are special order.  Please contact us.

Quantity

This product is available in 1mL and larger but in two different concentrations. The lower concentration is suited for mice, while the higher concentration is suitable for companion animals. For mice, the 1mL injection is suited for 5 injections. For orders larger than 1L, or for orders amounting over 10L per annum, please contact sales for quantity pricing.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.

Conjugation

This product comes coated with a proprietary polymer to increase circulation times. Ntracker™ contains a non-reactive methyl termination. Ntherapy™ contains many choices for reactive terminations. Many popular in vivo conjugations are available.

Introductory Kits

Unfortunately there are no kits available for this product at this time.

Shelf Life/Storage Temperature

This product is guaranteed for one year and may be stored at room temperature.

Toxicity

These products are non cytotoxic.

Sterilization

This product is sterilized.

Certifications

This product is manufactured using our audited ISO 9000/2001 quality control system. Every order comes with a Certification of Analysis that includes the following information. We use NIST traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for gold mass measurements

TEM (Phillips CM-100 100KV) for sizing

Ntracker™ is based on extensive research in laboratory, preclinical, toxicology, and more recently clinical trials. The technology is based on patented, patent pending, and proprietary methods. Nanopartz™ has the capacity for up to 1kg of Ntracker™product per day in its audited ISO 9000 facility. Ntherapy™ offers the same technology as Ntracker™ with the added advantage of popular in vivo conjugations and customer specified oligo and antibody choices.

This product has been extensively tested in mice and companion animals.

Photoacoustic is provided by our partner:

VisualSonics is the world leader in real-time, in vivo, high-resolution, micro-imaging systems, providing modalities specifically designed for preclinical research. VisualSonics has commercialized Vevo LAZR Technology, a state-of-the-art photoacoustic imaging system with inherent coregistration and capabilities for imaging gold nanorods in vivo. "Listen to the Light" - Photoacoustic imaging with the new Vevo LAZR System.

http://www.visualsonics.com/photoacoustics

 

 

 

  Nanopartz™ Ntracker™ Other Technologies
Circulation Time Long Low
Toxicity None Broad
Photothermal efficiency Highest recorded Low
Imaging potential Yes Very Limited
Drug Delivery potential Yes Very Limited
Tumor Loading High Low

 

 

 

  • Covalent bonds insure specificity, stability, long shelf life
  • Buffer Stability - stable from pH 4-9
  • No sodium azide
  • No BSA
  • Polymer coating insures no aggregation in high salts, reduced nonspecific binding
  • Stable
  • Well Characterized
  • Customer can select buffer
  • Customer can select gold nanoparticle type, size and/or SPR
  • Loading of all ligands is optimized
  • Customer can focus on research and not on Nanopartz expertise
  • Quick turnaround

 

 

 

"We have looked at many different gold nanoparticles samples from Nanopartz including spheres, rods, and microrods using single particle spectroscopy techniques and are extremely happy with the quality of the samples and the service provided by Nanopartz."

Stephan Link, PhD
Assistant Professor of Chemistry
Rice University

 


[HTML] Infrared-Transparent Gold Nanoparticles Converted by Tumors to Infrared Absorbers Cure Tumors in Mice by Photothermal Therapy

JF Hainfeld, MJ O'Connor, P Lin, L Qian, DN Slatkin… - PLoS ONE, 2014
... Permeability Measurements. Two 0.7 ml chambers were separated by a 0.4 µm
polycarbonate membrane (Millipore, Billerica, MA) [20]. One side was loaded with either
15 nm AuNPs or 10×45 nm Au nanorods (Nanopartz, Loveland, CO) in PBS. ...

Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas

G Von Maltzahn, JH Park, A Agrawal, NK Bandaru… - Cancer research, 2009 - AACR
... for their synthesis and characterization of CTAB-coated gold nanorods through Nanopartz... In
vivo tumor targeting and spectroscopic detection with surface-enhanced Raman ... Gold nanorod
assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell ...

Noninvasive< i> in vivo</i> spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes

KH Song, C Kim, K Maslov… - European journal of radiology, 2009 - Elsevier
... Noninvasive in vivo PA SLN mapping with gold nanorods has been successfully accomplished
in a rat ... top view and a bottom view of the dissected SLN, in which the nanorod-accumulated parts ...
Before the injection of the gold nanorods, a PA image was acquired as a control to ...

In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system

H Cui… - Medical physics, 2010 - link.aip.org
... used gold nanorods to enhance the PAI detection of tumor in an in vivo small animal ... Prior to animal
experiments, the peak optical absorption wavelength of gold nanorods (30-pm-700 ... Figure shows
that strong PA signals are generated from the nanorod solution, whereas the PA ...

[CITATION] NanoTech

T Pons, IL Medintz, KE Sapsford, S Higashiya…

NanoTech

T Pons, IL Medintz, KE Sapsford, S Higashiya… - Springer
... Nano keynotes at GOLD2009 Nanopartz have announced that a revolutionary new manufacturing
method has been developed for their nanorod products. ... However, the limitation on commercialising
gold nanorods for in-vivo and in-vitro applications has been toxicity. ...

GOLD NANOROD-siRNA COMPLEXES AND METHODS OF USING SAME

EJ Bergey, A Bonoiu, S Mahajan… - US Patent App. 12/ …, 2009 - Google Patents
... Alternatively, GNRs for use in the invention can be obtained from NANOPARTZ (Salt Lake ... can
be used to inhibit expression of target genes in vitro and in vivo... other than phosphodiester
linkages, provided the appropriate zeta potential of the gold nanorod/ RNA polynucleotide ...

Resolving rotational motions of nano-objects in engineered environments and live cells with goldnanorods and differential interference contrast microscopy

G Wang, W Sun, Y Luo… - Journal of the American …, 2010 - ACS Publications
... array, 16 × 16 μm pixel size) was used to record the dynamic in vivo and in ... bromide
(CTAB)-capped (25 × 73 nm, 1.3 × 10 11 particles/mL, Nanopartzgold nanorods. ... Briefly, excessive
surfactant was first removed from 1.0 mL of gold nanorod solution by centrifugation at 3000g ...

Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages

MM Janát-Amsbury, A Ray, CM Peterson… - European Journal of …, 2011 - Elsevier
... in size and shape while there were several non-rod-shaped particles in the gold nanorod samples. ...
Biodistribution of gold nanoparticles in ovarian tumor-bearing mice. The in vivo fate of the
nanoparticles and their transport across biological barriers by a particular administration ...

Cooperative nanomaterial system to sensitize, target, and treat tumors

JH Park, G Von Maltzahn, MJ Xu… - Proceedings of the …, 2010 - National Acad Sciences
... Preparation of Gold Nanorod, Magnetic Nanoworm, and Doxorubicin Liposomes. Gold nanorods
(NRs) were purchased from Nanopartz with a peak plasmon resonance at 800 nm and ... LPs were
intravenously injected in vivo to ensure control LPs and LyP1LPs exhibited similar ...

Plasmonic nanorod absorbers as orientation sensors

WS Chang, JW Ha… - Proceedings of the …, 2010 - National Acad Sciences
... surface plasmon resonance is mostly insensitive to the medium refractive index and nanorod
aspect ratio ... help with the photothermal imaging setup, Christian Schoen from Nanopartz for
supplying the gold nanospheres and ... 2005) Quantum dots for live cells, in vivo imaging, and ...

[HTML] A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging

D Pan, M Pramanik, A Senpan… - … of nanoscience and …, 2010 - ncbi.nlm.nih.gov
... Coated gold nanorods were purchased and used as received from Nanopartz, Inc. ... This work
introduced the concept of a “soft” type self-assembled gold nanorod contrast agent for efficient
NIR ... Further in vitro and in vivo works are warranted to realize the full potential of the ...

Laser optoacoustic spectroscopy of gold nanorods within a highly scattering medium

V Cunningham… - Optics letters, 2010 - opticsinfobase.org
... of optical absorbers lo- cated within a highly scattering medium and can easily be adapted for
in vivo trials ... the amplitude of the acoustic tran- sients generated at the surface of a methyl
terminated polymer conjugated gold nanorod colloidal solution (Nanopartz, Inc.) with ...

[DOC] PASTGIN for diagnosing, monitoring, and treating breast cancer

Y Cheng, A Goktug, K Liu… - duke.edu
... The multifunction polymeric shells built around gold nanorod (aspect ratio of 6.5) reduced their ...
The iron nanoparticles run about $200 per 10 g, ad gold nanoparticles cost $190 ... "Noninvasive
laser-induced photoacoustic tomography for structural and functional in vivo imaging of ...

Intra‐organ biodistribution of gold nanoparticles using intrinsic two‐photon‐induced photoluminescence

J Park, A Estrada, JA Schwartz… - Lasers in surgery …, 2010 - Wiley Online Library
... gold nanoshell; gold nanorod; two-photon-induced photoluminescence. ... particles were added
to the gold colloid suspension resulting in a silica particle covered with gold colloid. For in vivo
applications, a layer of 5,000 MW poly-(ethylene glycol) was added to the exterior shell ...

Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres

A Malugin, H Ghandehari - Journal of Applied Toxicology, 2010 - Wiley Online Library
... MATERIALS AND METHODS Plain, PEGylated spherical and PEGylated rod GNPs were obtained
from Nanopartz (Salt Lake City, UT, USA) and sterilized by filtra- tion upon receiving. ... PEG-modified
gold nanorod with a stealth character for in vivo applications. J. Control. ...

[PDF] Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

T Fernandez, AM Serrano, F del Pozo… - International Journal …, 2012 - dovepress.com
... The gold nanorods used in the hyperthermia experiments (30-10-808 Nanorodz; Nanopartz,
Salt Lake City, UT) were tuned to the laser ... clearly display gold nanorods in the cross-section of
the cell (B and C). Transmission electron micrographs of gold nanorod-labeled 1321N1 ...

Dual-Modality Single Particle Orientation and Rotational Tracking of Intracellular Transport of Nanocargos

W Sun, Y Gu, G Wang… - Analytical Chemistry, 2011 - ACS Publications
... were identified.(5-14) However, the understanding of the more complicated in vivo transport,
which ... CTAB)-capped (25 nm × 73 nm, 1.3 × 10 11 particles/mL, Nanopartzgold nanorods. ... Briefly,
excessive surfactant was first removed from 1.0 mL of the gold nanorod solution by ...

The effects of particle size, density and shape on margination of nanoparticles in microcirculation

R Toy, E Hayden, C Shoup, H Baskaran… - …, 2011 - iopscience.iop.org
... Gold nanospheres and gold nanorods were purchased from Nanopartz Inc ... 5 mol% PEG coverage
which has been shown to provide in vitro and in vivo stability (Johnsson ... order to obtain a
comparative indication of the effect of shape, the deposition of a gold nanorod was tested ...

Microsecond resolution of single-molecule rotation catalyzed by molecular motors.

T Hornung, J Martin, D Spetzler… - Methods in molecular …, 2011 - Springer
... HAuCl4 to form 4-nm seeds (15), but are also commercially available from Nanopartz Inc ... coli
F1-ATPase mol- ecules observed to rotate via single-molecule microscopy with gold nanorod
probes ... Klionsky, DJ, Brusilow, WS, and Simoni, R. D. (1984) In vivo evidence for the role of ...

NANOWORMS FOR IN VIVO TUMOR TARGETING

JH Park, L Zhang, AM Derfus, MJ Sailor… - US Patent App. 12/ …, 2010 - Google Patents
... A study on the uptake of gold nanoparticles into cultured tumor cells concluded that spherically
shaped particles have a higher probability of cell internalization than rod-shaped particles. When
nanopar- ticles are used in vivo, one of the most important issues is to avoid ...

Synthesis, Characterization, and Optical Response of Gold Nanoshells Used to Trigger Release from Liposomes

G Wu, A Mikhailovsky, HA Khant… - Methods in enzymology, 2009 - Elsevier
... HGNs are similar to silica core/gold nanoshells that have been used both in vitro and in vivo to
accumulate NIR light (Hirsch et al., 2003), except that HGNs have a hollow core, which allows
easier synthesis, (Prevo et al., 2008) smaller overall dimensions ( [Prevo et al., 2008 ...

Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation

D DasGupta, G von Maltzahn, S Ghosh… - Applied Physics …, 2009 - link.aip.org
... 1. Color online Photothermal modeling of gold nanorod tumor heating a The nanorod heating setup ...
time surface temperature assessment via infrared thermography FLIR Thermacam to facilitate
comparison of model predictions against in vivo experimental recordings. ...

Imaging and Absolute Extinction Cross-Section Measurements of Nanorods and Nanowires through Polarization Modulation Microscopy†

CR Carey, T LeBel, D Crisostomo… - The Journal of …, 2010 - ACS Publications
... These particles possess a strong resonance in the near-IR (the longitudinal plasmon resonance)
that is almost perfectly polarized, ie, σ ≈ 0.(12) Images of a gold nanorod recorded at 800 nm
for two different angles of the λ/2-waveplate are shown in Figures 2, panels a and b ...

Use of near-infrared luminescent gold nanoclusters for detection of macrophages

V Sapozhnikova, B Willsey, R Asmis… - Journal of Biomedical …, 2012 - link.aip.org
... atoms have also been shown to produce emissions with quantum yields as high as 6%. These
nanoparticles show promise for in vivo identification of ... The nanorods purchased from Nanopartz,
Inc ... Lyvers, DPet al., “Gold nanorod arrays as plasmonic cavity resonators,” ACS Nano ...

Mechanisms of nanoparticle-mediated photomechanical cell damage

S Peeters, M Kitz, S Preisser… - Biomedical Optics …, 2012 - opticsinfobase.org
... K. Liao, C. Poe, S. Jhan, AA Ding, and YN Wu, “In vivo photoacoustic molecular ... L. Tong and
J.-X. Cheng, “Gold nanorod-mediated photothermolysis induces apoptosis of macrophages via ...
Petri dishes and grown for 1-2 days before incubation with colloidal gold nanoparticles of ...

Enhanced visualization of biodegradable polymeric vascular scaffolds by incorporation of gold, silver and magnetite nanoparticles

F Luderer, I Begerow, W Schmidt… - Journal of …, 2012 - jba.sagepub.com
... nm and gold nanospheres with a diameter of 100nm were purchased from Nanopartz (Loveland,
USA ... Hence, in a potential in vivo setting the incorporated nanopar- ticles should be firmly ... P(4HB)
minitube samples doped with different nanoparticles: 0.1% (w) gold nanoparticle (a ...

Photothermal multispectral image cytometry for quantitative histology of nanoparticles and micrometastasis in intact, stained and selectively burned tissues

DA Nedosekin, EV Shashkov, EI Galanzha… - Cytometry Part …, 2010 - Wiley Online Library
... cells in a thin layer of whole blood (33), label-free mapping of real melanoma metastasis at the
single cell level both in vivo and in ... Gold nanorods (GNRs) with axial size 30 nm, diameter 10
nm and peak absorption at 740 nm were purchased from Nanopartz (Loveland, CO). ...

[PDF] Biocompatible Microparticles for Optically Driven On-demand Controlled Drug Release of Methotrexate

K Adlon, R Bartels, S Briggs, S Rusk… - pages.drexel.edu
... Gold nanorods from Nanopartz with a peak absorptive wavelength of 780nm were purchased
for the main component of the gold-NIR, light-to-heat energy ... The gold nanorod solution will be
pipetted into the cuvette, and the thermistor will be placed under the aluminum bottom. ...

[PDF] Nonlinear optics in quantum-confined and surface-plasmon structures

L Wang - 2010 - repository.unm.edu
... 60 5.3. Surface-plasmon enhanced absorption ..... 61 5.3.1. Enhanced linear absorption using
spherical gold nanoparticles ..... 61 5.3.2. Enhanced nonlinear absorption using gold nanorods ..... ...

Transient photothermal spectra of plasmonic nanobubbles

E Lukianova-Hleb, E Sassaroli, A Jones… - Langmuir, 2012 - ACS Publications
... under room temperature) (Nanopartz Inc, Loveland, CO) and synthesized gold hollow
nanoshells (NS, 50±7 nm diameter, 2.7±0.8 nm thickness, optical extinction peak
at 665 nm under the same conditions) following established ...

Absorption and scattering of single plasmonic nanoparticles

JW Ha - 2010 - dspace.rice.edu
... 2-1. Materials and Chemicals Gold nanospheres, 73 nm long (part #: 30-25-700) and 86 nm long
(part #: 30-25- 730) AuNRs were obtained from Nanopartz. 2.5 um long gold nanowires were
synthesized and obtained from Prof. Zubarev's group at Rice University. Microscope ...

Ultrasharp nonlinear photothermal and photoacoustic resonances and holes beyond the spectral limit

VP Zharov - Nature Photonics, 2011 - nature.com
... media, multiphoton and Raman spectroscopy, microscopy beyond the diffraction limit, PA tweezers
and in vivo detection of ... Ultrasharp PT resonances made it possible to easily identify each nanorod
in a mixture of six nanorods that ... Figure 2: Nonlinear spectra of gold nanorods. ...

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

TA Brown, AN Tkachuk, G Shtengel… - … and cellular biology, 2011 - Am Soc Microbiol
... Gold nanorod particles (NanoPartz) were then applied by application of a 0.5% solution for 5
min. After being rinsed, the glass was coated with biotin (1 mg/ml)-BSA-PBS (Sigma Chemical
A8549) followed by streptavidin–PBS (Sigma Chemical S462) (1 mg/ml solution). ...

Methods and systems for treatment and/or diagnosis

SN Bhatia, GA Von Maltzahn - US Patent App. 12/716,217, 2010 - Google Patents
... 7A-7C illustrate specific fibrinogen tropism to heated tumors, in one set of
embodiments; [0023] FIGS. 8A-8E illustrate nanorod-directed tumor heating and
fibrinogen deposition, in another set of embodi- ments; [0024] FIGS. ...

[PDF] Laser Tissue Welding: Study of the Mechanism and Optimization of the Technique

P Matteini - unifi.it
... modifications in the tissue and to explore the possibility of improving the laser welding
technique by the use of gold nanoparticles as new chromophores. Page 9. ... performed on ex
vivo pig eyes; the healing process was then studied in vivo in rabbits. The ...

INTEGRATION OF VERY SHORT ELECTRIC PULSES FOR MINIMALLY TO NONINVASIVE ELECTROPORATION

R Davalos, B Christopher… - US Patent App. 12/757,901, 2010 - Google Patents
... CI. A61B 18/18 A61B 5/055 A61B 8/00 A61B 5/05 (2006.01) (2006.01) (2006.01) (2006.01)
(52) US CI 600/411; 606/41; 600/439; 600/407 (57) ABSTRACT The present invention provides
methods, devices, and sys- tems for in vivo treatment of cell proliferative disorders. ...

Engineering of Micro‐and Nanostructured Surfaces with Anisotropic Geometries and Properties

S Tawfick, M De Volder, D Copic… - Advanced …, 2012 - Wiley Online Library
... (g) Multiple domains of silver nanorods made by evaporative self-assembly. Reproduced with
permission from http://www.nanopartz.com/. Download figure to PowerPoint. ... Reproduced with
permission,27 copyright 2007 AIP. (f) Gold helices made by two-photon lithography. ...

[PDF] Optoelectronic Manipulation, Assembly, and Patterning of Nanoparticles

A Jamshidi, MC Wu - University of California at Berkeley, 2009 - eecs.berkeley.edu
... 66 5.2.3 DEP Manipulation of Spherical Gold Nanoparticles.....68 5.3 IN-SITU SURFACE
ENHANCED RAMAN SPECTROSCOPY (SERS) USING METALLIC NANOCRYSTALS ... Figure
5.5 Trapping and transport of five 250 nm gold nanoparticles. ...