Nanopartz Microgold

Nanopartz™ Microgold are rod shaped gold nanoparticles manufactured using proprietary methods that result in exact sizes, highly monodisperse sizes and shapes, long shelf lives, along with significantly improved reactivity. Microgold are 75-150 nanometers in diameter and up to 2 microns in length. Microgold are the largest known "nanoparticles" available - and the largest that can still be considered nanoparticles. These particles match the wavelength of light in the longitudinal dimension providing single particle detection under white light microscopy with simple instrumentation. They have approximately 100 times the scattering cross section as a 100 nm spherical gold nanoparticle, 100,000 to 1,000,000 times the scattering of a 1.4 nm gold nanoparticle. As with all of Nanopartz products, they are highly monodisperse. Every batch is completely characterized including size, monodispersity, aggregation, residual chemicals, and concentration. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped same day. This product comes in two concentrations, regular OD=0.05 (0.05mg/mL), and highly concentrated OD=5 (5mg/mL) in DI water, purified of residual reactants to <0.1%. These particles are are available non-covalently capped with our own proprietary carboxylic acid, citrate, and many other adsorbed polymers. These capping agents are readily replaced with covalent and charge chemistries.

These particles are not manufactured in citrate. Citrate and the other ligands are functionalized after manufacturing allowing for a minimal, controlled amount of ligand to be used.

Want to know more? Go to All About Microgold

 

image_0

Product Image Left to Right, A13-500 to A13-2000


Gold Nanocubes UV VIS

 

Part # Diameter (nm) Length (nm) Aspect Ratio Peak SPR Wave (nm) SPR OD (1cm) Microgold /mL Wt. conc (mg/ml) SPR Molar Ext. (M-1cm-1)
A13-500 75 500 6.7 510 0.05 1.24E+09 0.05 2.43E+07
A13-1000 100 1000 10 510 0.05 3.42E+08 0.1 8.78E+07
A13-2000 150 2000 13.3 510 0.05 7.53E+07 0.1 3.98E+08

 


Home
» A13 Microgold
Microgold with Adsorbed Ligands
Microgold with Adsorbed Ligands
Part Number: A13
Options: -(LENGTH)-(ADSORBED LIGAND)-(BUFFER)-(WT)-(VOL)-(CS)-(EP)

These are Microgold with adsorbed ligands including citrate and CTAB. Example part number of a 1000nm long Microgold, citrate adsorbed ligand, PBS, 0.25mg in 5mL PBS would be: A13-1000-CIT-PBS-0.25-5
Specification Table / COAs Capping Agents SDS/S&H/Tech Notes Additional Info

Specification Table


Part # Diameter (nm) Length (nm) Aspect Ratio Peak SPR Wave (nm) SPR OD (1cm) Microgold /mL Wt. conc (mg/ml) SPR Molar Ext. (M-1cm-1)
A13-500 75 500 6.7 510 0.05 1.24E+09 0.05 2.43E+07
A13-1000 100 1000 10 510 0.05 3.42E+08 0.1 8.78E+07


Capping Agent Comparison


MW MW (g/mole) Zeta Charge (mV) Salt Resistant? Concentration Sensitive? Easy to adsorb Proteins? Easy to Thiolate? Shelf life at 4C
Citrate 192 -35 1.5mM  Yes  Yes  Yes 6 months
Nanopartz Carboxylic Acid 212 -30 15mM Less than Citrate Better than Citrate Better than Citrate years
PEI 100K 30 150mM No Yes Yes 6 months
PAA 10K -30 150mM No Yes Yes 6 months
PAH 10K 20 150mM No Yes Yes 6 months
PAA 40K -10 0.5M No Yes Yes 6 months
CTAB 364 35 0.5M Yes Yes No 6 months
BSA 66K -15 0.5M No No No 6 months

 

Options:
500nm: 75x500nm
1000nm: 100x1000nm
2000nm: 150x2000nm
CTAB (Cetyltrimethylammonium bromide)
CIT (Citrate)
PEI (100K Polyethylenimine)
PAH (25K Polyallylamine hydrochloride)
PAA (10K Polyacrylic acid)
PVP (40K Polyvinylpyrrolidone)
BSA (Bovine Serum Albumin)
DIH (18MEG DD DI Water)
PBS (Phosphate Buffer Saline pH=7)
MES (pH=4.7)
SOBO (Sodium Borate pH=8.5)
TRIS (pH=7.2)
0.05mg = OD=0.05
5mg = OD=5
Price$1,800.00

 

Gold Nanoparticles PEI
PEI
Gold Nanoparticles PAA
PAA
Gold Nanoparticles PAH
PAH
Gold Nanoparticles PVP
PVP
Gold Nanoparticles Citrate
Citrate
Gold Nanoparticles CTAB
CTAB
Gold Nanoparticles Nanopartz Carboxylic Acid
Nanopartz Carboxylic Acid

 

MW (g/mole)
Zeta Charge (mV)
Salt resistant?
Concentration Sensitive?
Easy to adsorb proteins?
Easy to thiolate?
Shelf Life at 4C
Citrate
192
-35
1.5mM
Yes
Yes
Yes
6 months
Nanopartz Carboxylic Acid
212
-30
15mM
Less than Citrate
Better than Citrate
Better than Citrate
years
PEI
100K
30
150mM
No
Yes
Yes
6 months
PAA
10K
-30
150mM
No
Yes
Yes
6 months
PAH
10K
20
150mM
No
Yes
Yes
6 months
PVP
40K
-10
0.5M
No
No
Yes
6 months
CTAB
364
35
0.5M
Yes
No
No
6 months
BSA
66K
-15
0.5M
No
No
No
6 months

 

Composition

These bare Microgold are shipped in  DI water in 5mM CTAB.

Custom Formulation

Diameters 75 to 150nm, lengths 500 to 2000nm.  Other sizes are special order.  Please contact us.

Quantity

This product is available in 5mL and larger. For orders larger than 100mL, or for orders amounting over 10L per annum, please contact sales for quantity pricing.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.

Conjugations

This product comes standard with CTAB.

Shelf Life/Storage Temperature

This product is guaranteed for six months and should be stored at 4°C after opening. Care must be taken to only use sterile glassware when working with this product.

Toxicity

This product is known to be cytotoxic.

Certifications

This product is manufactured using our audited ISO 9000 quality control system. Every order comes with a Certificate of Analysis. We use NIST traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for gold mass measurements

TEM (Phillips CM-100 100KV) for sizing

Spherical Gold Nanoparticles UV VIS

 

Can I use these bare microgold particles in my in-vitro experiments?

The CTAB provides a positive zeta potential that is very attractive for intercellular uptake. However, the CTAB is not covalently bound and is known to be cytotoxic. We recommend our MUTAB coated microgold that you can find in our in-vitro section.

What is the SPR for this product?

There is no Surface Plasmon Resonance for this particle as the diameter and length are too large, so these are not recommended for dark field microscopy. However, they are large enough to reflect light and are very advantageous for bright field microscopy.

Why are these particle so advantageous for in-vitro applications?

They have been shown to be the perfect size for intercellular uptake.

 

"I just wanted to say thank you! I am very proud of this research and I could not have done it without your nanoparticles and support. Look in the future for published work by us using these nanoparticles as well. Should be happening in the next few months. Thanks again."

Kellie Waterman 
Graduate Student 
Worcester Polytechnic University

 

Shape-dependent oriented trapping and scaffolding of plasmonic nanoparticles by topological defects for self-assembly of colloidal dimers in liquid crystals

B Senyuk, JS Evans, PJ Ackerman, T Lee, P Manna… - Nano …, 2012 - ACS Publications
... and surface chemistry (Table 1). Ethanol dispersions of microgolds (MGs), starfruits (SFs),
nanobursts (NBs) and nanorods (GNRs) with NSol(akyl acrylate) polymer conjugation (Figure
1a–d) were obtained from Nanopartz, Inc. ... Microgold (MG), NSol(akyl acrylate), 150, 800, 235, ...

 

The manufacturing method for these microparticles are based on our proprietary methods. This invention allows for the manufacturing of highly monodisperse gold microparticles. Micron sized particles are advantageous for white light microscopy applications as single particles can be seen under 40x objectives. This product replaces silver growth chemistries and its size is particularly advantageous in cellular uptake.

All of these "bare" particles are capped with ligands that are easily replaced with thiol and charge chemistries.

  Nanopartz™ Microgold Other Technologies
Monodispersity High (<10%) n/a
Size Accuracy High (25nm) n/a
Linewidths Narrow n/a
Storage lifetime Years n/a
Ability to ligand exchange Easy n/a

 

  • Largest know gold nanomaterial.
  • Single particles can be seen in white light microscopy.
  • Many conjugation options.
  • Advantageous size for intracellular uptake.
  • Perfect for microscopy labeling without silver growth.
  • Applications in tribological additives.
  • Large size enables use as labels in electron microscopy.

Example part number is A13-500-CIT-DIH-1-5-CS-EP where:

A13 - Product family number for Microgold

500 - Length in nanometers. Other choices are 1000, 2000

CIT - Capping ligand, in this case Citrate. Other choices are NPC, CTAB, PAA, PVP, PEI, PAH, PSS, BSA

DIH - Buffer, in this case 18MEG DI water. Other choices are PBS, MES, Sodium Borate, TRIS

1 - 0.05mg/mL concentration, other choice is 100 which is 5mg/mL

5 - Volume (mL). Other choices are 25mL.

CS - Certified Sterilized - Though the product come sterilized, this option includes testing and certification.

EP - Endotoxin Purified - The product is endotoxin purified and certified.

How to Order