Ntherapy

PH: 866.721.7796
FX: 866.811.NANO(6266)

Nanopartz^TM has developed and optimized Ntherapy^TMnanorods specifically for use in biological, preclinical, and in vivo applications. Ntherapy^TMnanorods are coated in a dense layer of hydrophilic polymers with amine, carboxyl, and neutravidin terminations. The polymer shields the gold surface and gives the particles long circulation times in vivo while the varied terminations provide a multitude of conjugation options. As opposed to other commercially available nanoparticles with short circulation times, such as quantum dots, Ntherapy^TM nanorods have been rigorously tested in vivo to yield superior circulation times a variety of mammalian species. Ntherapy^TM nanorods are available with transverse plasmon resonance peaks in the near-infrared and are easily conjugated to antibodies, oligos and other targets. A special amine formulation allow for a negative potential increasing in vivo circulation times.

Composition

The gold nanorods are shipped in DI water at pH = 7.

Custom Formulation and Production

10 nm axial sized nanorods are used for wavelengths 700 nm, 750 nm, 780 nm, 808 nm, and 850 nm since the 10 nm size offers the highest photothermal conversion per gram. Refer to application and technical notes.

Quantity

This product is available in highly concentrated (OD 50) in 1 ml and 5 ml sizes which amounts to 50 and 250 OD-mLs. For a 20g mouse, 0.150 mL per injection is required.

Delivery

All orders come with a batch distribution curve for quality assurance. Standard sizes are in stock. Special order sizes will be shipped in two weeks or less. All shipments are sent Fed Ex Standard Overnight delivery. No shipments on Fridays.

Conjugation

The conjugation chemistry for attaching the amine and carboxyl as well as biotin and neutravidin binding chemistries are well known. We also offer conjugation kits that establish protocols for standard binding. Neutravidin is our replacement for streptavidin, offering better binding kinetics while reducing non-specific binding. See application notes for more information.

Specification Overview

In batch size variation	< 10% CV
Shape monodispersity	>95% nanorods
Longitudinal size	10 nm
Wavelength coverage	700-850 nm

Part # Nanorod (Axial Diam/Peak LSPR)	Transverse Diameter (nm)	Long Size (nm)	Peak LSPR Wave (nm)	LSPR OD (AU)	Peak TSPR Wave (nm)	TSPR OD (AU)	NPS/ml	Wt. conc (mg/ml)	Wt. %	PPM
30-P(A,C,N)-850	10	45	850	50.0	512	12.50	2.6E+13	1785.7	0.1786%	1786
30-P(A,C,N)-808	10	41	808	50.0	512	12.50	2.9E+13	1805.6	0.1806%	1806
30-P(A,C,N)-780	10	38	780	50.0	512	12.50	3.1E+13	1745.8	0.1746%	1746
30-P(A,C,N)-750	10	35	750	50.0	512	12.50	3.2E+13	1670.7	0.1671%	1671
30-P(A,C,N)-700	10	29	700	50.0	512	12.50	3.3E+13	1483.6	0.1484%	1484

LSPR = Longitudinal SPR peak
TSPR = Transverse SPR peak
Shape monodispersity (% rods) > 95%
Size variation +/-10% (both dimensions)
Aspect ratio variation = Peak LSPR accuracy/96
All specs typical. May vary batch to batch. Exact values are measured for each batch
Part # example: 780 nm Amine Ntherapy 1 mL OD 50 would be 30-PA-780-50

Coverage

Part #	# Active sites/particle
30-P(A,C,N)-850	56
30-P(A,C,N)-808	51
30-P(A,C,N)-780	47
30-P(A,C,N)-750	44
30-P(A,C,N)-700	38

Zeta Potential

Conjugation	Charge (mV)
Methyl	0
Carboxyl	-20
Amine	-10
Neutravidin	-0.5

Product and Price List

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30-PA-700-50	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Amine-Polymer, 50 OD-mL	$480
30-PA-700-250	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Amine-Polymer, 250 OD-mL	$1,920
30-PA-750-50	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Amine-Polymer, 50 OD-mL	$480
30-PA-750-250	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Amine-Polymer, 250 OD-mL	$1,920
30-PA-780-50	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Amine-Polymer, 50 OD-mL	$480
30-PA-780-250	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Amine-Polymer, 250 OD-mL	$1,920
30-PA-808-50	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Amine-Polymer, 50 OD-mL	$480
30-PA-808-250	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Amine-Polymer, 250 OD-mL	$1,920
30-PA-850-50	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Amine-Polymer, 50 OD-mL	$480
30-PA-850-250	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Amine-Polymer, 250 OD-mL	$1,920

30-PC-700-50	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Carboxyl-Polymer, 50 OD-mL	$480
30-PC-700-250	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Carboxyl-Polymer, 250 OD-mL	$1,920
30-PC-750-50	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Carboxyl-Polymer, 50 OD-mL	$480
30-PC-750-250	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Carboxyl-Polymer, 250 OD-mL	$1,920
30-PC-780-50	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Carboxyl-Polymer, 50 OD-mL	$480
30-PC-780-250	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Carboxyl-Polymer, 250 OD-mL	$1,920
30-PC-808-50	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Carboxyl-Polymer, 50 OD-mL	$480
30-PC-808-250	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Carboxyl-Polymer, 250 OD-mL	$1,920
30-PC-850-50	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Carboxyl-Polymer, 50 OD-mL	$480
30-PC-850-250	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Carboxyl-Polymer, 250 OD-mL	$1,920

30-PN-700-50	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Neutravidin-Polymer, 50 OD-mL	$520
30-PN-700-250	Ntherapy In-Vivo GNRs 10 nm, SPR=700 nm, Neutravidin-Polymer, 250 OD-mL	$2,080
30-PN-750-50	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Neutravidin-Polymer, 50 OD-mL	$520
30-PN-750-250	Ntherapy In-Vivo GNRs 10 nm, SPR=750 nm, Neutravidin-Polymer, 250 OD-mL	$2,080
30-PN-780-50	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Neutravidin-Polymer, 50 OD-mL	$520
30-PN-780-250	Ntherapy In-Vivo GNRs 10 nm, SPR=780 nm, Neutravidin-Polymer, 250 OD-mL	$2,080
30-PN-808-50	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Neutravidin-Polymer, 50 OD-mL	$520
30-PN-808-250	Ntherapy In-Vivo GNRs 10 nm, SPR=808 nm, Neutravidin-Polymer, 250 OD-mL	$2,080
30-PN-850-50	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Neutravidin-Polymer, 50 OD-mL	$520
30-PN-850-250	Ntherapy In-Vivo GNRs 10 nm, SPR=850 nm, Neutravidin-Polymer, 250 OD-mL	$2,080