Nanopartz^TM has developed and optimized Nsers^TM surface enhance Raman labeled nanorods for the near infrared specifically for use in biological, preclinical, in vivo, as well as in material applications. Nsers^TM nanorods are coated in a caged polymer coating that shields the gold surface and gives the particles ultra long-circulation times in vivo.  For in vivo use, as opposed to other commercially available nanoparticles with short circulation times, such as quantum dots, Nsers^TM nanorods have been rigorously tested to yield superior circulation times in a variety of mammalian species.  For material applications, Nsers^TM are perfect for long stability times in a host of mediums. 

Nsers^TM nanorods are 1000 times more sensitive than Quantum Dots and other fluorophores (attomolar), do not photobleach, and provide characteristic signatures for concurrent labeling from a single laser source.

Three labels are available, each one is available with methyl polymer caged conjugations.   

 Features

• Optimized for 780-810 nm  laser wavelength excitations

• Long circulation times in vivo

• Low cytotoxicity in vivo and in vitro.  Gold is FDA approved for rheumatoid arthritis. (Cytotoxicity is based on CTAB capping agent concentration and not on the gold itself)

• Great photothermal conversion efficiency in the near IR

• Facile conjugation ability

• Attomolar sensitivities

• Three labels from one excitation source
   

Benefits

•  Monodisperse shapes and sizes in production volumes satisfies high volume applications. Tunable scattering/absorptions in the NIR create good for multi-label imaging and therapy

• NIR absorptions are advantageous for in vivo applications at the peak transmission window of skin and tissue

• High photothermal conversion is advantageous for thermally destroying tumors and viruses in vivo

• Attomolar sensitivities are advantageous for in vivo imaging

• Easy conjugations provide necessary vehicle for gene therapy

Composition

The labels are shipped in PBS at pH=7.4. 

Custom Formulation and Production

Nsers^TM  are best used with laser wavelengths from  780-808 nm.  Refer to application and technical notes.

Quantity

This product is available in highly concentrated (OD 50) 1 mL sizes.  For a 20g mouse, 0.150 mL per injection is required. 

Delivery

All orders come with a Certificate of Analysis for quality assurance.  Standard sizes are in stock.  Special order sizes will be shipped in two weeks or less.  All shipments are sent Fed Ex Standard Overnight delivery.  No shipments on Fridays. 

Conjugation

None at this time

Specification Overview

Product and Price List

To begin online shopping push on

To begin online shopping push on

Applications

In-Vivo

Imaging

      Photoacoustic Imaging

            Optical Coherence Tomography

            Two photon fluorescence

            SERS

 Therapeutics

      Photothermal

            Cancer

            Viral

            Drug Delivery/Gene Therapy